Download DNB 2015 Dec PHARMA P IV Question Paper

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FINAL EXAM

DECEMBER 2015

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PHARMACOLOGY

PAPER - IV

Time : 3 hours

Max. Marks : 100

Important instructions:

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• Attempt all questions in order.
• Each question carries 10 marks.
• Do not leave any blank pages between two answers.
• Answer all the parts of a single question together.
• Draw table/diagrams/flowcharts wherever appropriate.

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• Read the question carefully and answer to the point neatly and legibly.
• Indicate the question number correctly for the answer in the margin space.
• Start the answer to a question on a fresh page or leave adequate space between two answers.

Write short notes on:

1. a) Enumerate patient safety and pharmacovigilance.
   

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   b) Pharmacovigilance programme of India(PVPI). 5+5
2. Mention different endothelin receptors, drug acting on endothelin receptor, their therapeutic use, adverse effects and precautions.
3. Procedure for Investigational New Drug (IND) and New Drug Applications (NDA) as per Schedule Y.
4. a) Proof of concept in clinical trial.
   b) Therapeutic misconception 5+5

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5. a) Define biomarker.
   b) Uses of biomarkers for personalized medicine.
   c) Biomarker regulatory validation:
6. a) Therapeutic drug monitoring of immunosuppressive drug. 5+5
   b) Accreditation of the therapeutic drug monitoring laboratory.

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7. a) Signal review of medicinal product
   b) Biovigilance 5+5
8. a) Novel analgesic targets for treatment of pain.
   b) Neuronal nicotinic receptors as novel targets for analgesics. 5+5
9. a) Compensation in clinical trial.
   

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   b) Role of Ethics Committee as per amendment of Schedule Y. 5+5
10. a) Enumerate various histaminic receptors.
    b) Clinical use of anti-histaminics, adverse effects and precautions. 2+(3+3+2)

POSSESSION / USE OF CELL PHONES IS NOT PERMITTED INSIDE THE HALL.

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