Download DNB 2015 Dec BIOCHEMISTRY I Question Paper

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FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2015
BIOCHEMISTRY
PAPER - |
BIO/D/15/03/1

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Important instructions:

1. Attempt all questions in order.
2. Each question carries 10 marks.
3. Read the question carefully and answer to the point neatly and legibly.

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4. Do not leave any blank pages between two answers.
5. Indicate the question number correctly for the answer in the margin space.
6. Answer all the parts of a single question together.
7. Start the answer to a question on a fresh page or leave adequate space between two answers.
8. Draw table/diagrams/flowcharts wherever appropriate.

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1. Write short notes on:
   1. Principles used by enzyme for catalyzing a reaction. (3+7)
   2. Mechanism of action of ‘Chymotrypsin’.
2. Keys to successful evaluation of new analytical laboratory method. (10)
3. 1. What are the functional and non-functional plasma enzymes? (2+3+5)

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   2. Enumerate the marker enzymes for cardiac disease.
   3. With the help of a graph give the time course of their elevation in blood of myocardial infarction patients.
4. What are immobilized enzymes? With the help of suitable examples give their applications. (4+6)
5. 1. Analytical performance criteria (2x5=10)

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   2. Frequency distribution
   3. Random Sampling
   4. Calibration
   5. Linearity

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6. 1. Types of pre-analytical variables. (4)
   2. Total quality management. (6)
7. What is glycated haemoglobin? What is its normal level in blood? What is its clinical utility? How is it measured? (2+1+2+5)
8. What is receiver operating characteristics (ROC) plot? How is it beneficial in interpreting study results? (3+7)

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9. What is anion gap? What is its clinical significance? (3+7)
10. What type of lipid profile is seen in diabetes mellitus (D.M.) patients? What is the biochemical basis for it? (3+7)