FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2014
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PATHOLOGY
PAPER - IV
PATH/J/14/32/IV
Time : 3 hours
Max. Marks : 100
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Important instructions:
- Attempt all questions in order.
- Each question carries 10 marks.
- Read the question carefully and answer to the point neatly and legibly.
- Do not leave any blank pages between two answers.
- Indicate the question number correctly for the answer in the margin space.
- Answer all the parts of a single question together.
- Start the answer to a question on a fresh page or leave adequate space between two answers.
- Draw table/diagrams/flowcharts wherever appropriate.
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Write short note on:
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- What are the various red cell indices measured by automated 5+5 hematology analyzers? What is their role in evaluation of anemia?
- Describe the ISTH criteria for diagnosis and laboratory investigations for diagnosis of anti-phospholipid syndrome (APLA).
- a) Hematologic manifestations of HIV infection 5+5
b) Transfusion associated GVHD - Describe the clinicopathologic spectrum, immune response and 3+3+4 laboratory diagnosis of Epstein Barr Virus infection.
- a) Blast equivalents in diagnosis of acute leukemias 5+5
b) Molecular pathogenesis of B-thalassemia - a) Pathogenesis and laboratory diagnosis of Paroxysmal Nocturnal Hemoglobinuria (PNH) 5+5
b) Pure red cell aplasia - Enumerate chronic lymphoproliferative disorders. Discuss the 3+7 role of morphology and immunophenotyping in diagnosing these cases.
- a) Nucleic acid technology in blood donor screening 5+5
b) Hemovigilance - a) Congenital morphological anomalies of leukocytes 5+5
b) Platelet function disorders - a) NK cell lymphoma 5+5
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b) Prognostic factors in acute lymphoblastic leukemia
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