Download DNB 2013 June PATHOLOGY P IV Question Paper

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FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2013

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Time : 3 hours
Max. Marks : 100

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Attempt all questions in order.
Each question carries 10 marks.

1. Discuss the classification and morphology of leprosy. What are the various reactions encountered in leprosy. (7+3)
2. Write short notes on: (5+5)
   1. Polarising microscopy in diagnostic pathology
   2. Role of prostaglandins in acute inflammation

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3. What is Epithelial Mesenchymal Transition (EMT)? What are its molecular pathways and significance in malignancy? (4+3+3)
4. Write short notes on: (5+5)
   1. Pathogenesis of vascular spread of tumours.
   2. Plasticity of stem cells and its clinical significance.

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5. Define innate and adaptive immunity. Describe the cellular and molecular mechanisms of innate immunity. (3+7)
6. Describe the various mechanisms of recognition and rejection of allografts. (7+3)
   Describe in brief the morphology, immunocytochemistry and electron microscopy of chronic antibody mediated kidney transplant rejection.
7. Give the various causes with examples of genetic predisposition to cancer. (7+3)
   What is the interaction between genetic and non genetic factors?

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8. Write short notes on: (7+3)
   1. Gene microarray technology.
   2. Tissue microarrays
9. Describe the genetic abnormalities, pathophysiology and clinical correlation of cystic fibrosis (mucoviscidosis). (4+3+3)
10. Enlist the various lysosomal disorders along with their specific defects. (4+6)
    

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    Describe the clinical features and pathology of different types of Niemann-Pick disease.

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.

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