Download PTU M.Pharm 2020 March 2nd Sem 74955 Advanced Spectral Analysis Question Paper

Download PTU (I.K. Gujral Punjab Technical University Jalandhar (IKGPTU) M.Pharma 2020 March (Master of Pharmacy) 2nd Sem 74955 Advanced Spectral Analysis Previous Question Paper

1 | M-74955 (S31)-585

Roll No. Total No. of Pages : 02
Total No. of Questions : 06
M.Pharma(Pharmaceutical Chemistry) (2017 & Onwards) (Sem.?2)
ADVANCED SPECTRAL ANALYSIS
Subject Code : MPC-201T
M.Code : 74955
Time : 3 Hrs. Max. Marks : 75
INSTRUCTIONS TO CANDIDATES :
1. Attempt any FIVE questions out of SIX questions.
2. Each question carries FIFTEEN marks.

1. a) Describe Woodward-Fieser rule for the calculation of ?
max
for conjugated dienes. 5
b) Use the Woodward-Fieser rule to calculate ?
max
for following compounds : 5

c) Describe the frequency shift related to stretching frequencies of C=0 under the
influence of intermolecular and intramolecular hydrogen bond in common organic
compounds. 5
2. a) What is the principle of COSY experiment of 2D-NMR? Describe its advantages over
the other experiments. 7
b) Predict the multiplicity of signals in 1HNMR spectra of :
i) CH
3
COCH(CH
3
)
2
4
ii) CH
3
COOCH(CH
3
)
2
4
3. a) Explain the importance of following in interpretation of mass spectra of organic
compounds :
i) Isotopic peak 4
ii) McLafferty rearrangement 4
b) Predict the masses of ions produced in mass spectrum of hexene by McLafferty
rearrangement. 7
(a) (b)
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1 | M-74955 (S31)-585

Roll No. Total No. of Pages : 02
Total No. of Questions : 06
M.Pharma(Pharmaceutical Chemistry) (2017 & Onwards) (Sem.?2)
ADVANCED SPECTRAL ANALYSIS
Subject Code : MPC-201T
M.Code : 74955
Time : 3 Hrs. Max. Marks : 75
INSTRUCTIONS TO CANDIDATES :
1. Attempt any FIVE questions out of SIX questions.
2. Each question carries FIFTEEN marks.

1. a) Describe Woodward-Fieser rule for the calculation of ?
max
for conjugated dienes. 5
b) Use the Woodward-Fieser rule to calculate ?
max
for following compounds : 5

c) Describe the frequency shift related to stretching frequencies of C=0 under the
influence of intermolecular and intramolecular hydrogen bond in common organic
compounds. 5
2. a) What is the principle of COSY experiment of 2D-NMR? Describe its advantages over
the other experiments. 7
b) Predict the multiplicity of signals in 1HNMR spectra of :
i) CH
3
COCH(CH
3
)
2
4
ii) CH
3
COOCH(CH
3
)
2
4
3. a) Explain the importance of following in interpretation of mass spectra of organic
compounds :
i) Isotopic peak 4
ii) McLafferty rearrangement 4
b) Predict the masses of ions produced in mass spectrum of hexene by McLafferty
rearrangement. 7
(a) (b)
2 | M-74955 (S31)-585

4. Explain the principle and describe the applications of :
a) LC-MS 7.5
b) Super critical fluid chromatography. 7.5
5. a) Describe the principle and instrumentation of DSC. 7.5
b) Describe the instrumentation and applications of Raman spectroscopy. 7.5
6. a) Explain the principle and describe procedure of radioimmunoassay of insulin. 7.5
b) Describe the applications of ion exchange chromatography. 7.5










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