2019 Scheme
Q.P. Code: 215001
Reg. no.: .....................
Second Professional MBBS Degree Regular/Supplementary Examinations
December 2024
Time: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
Indicate the question number correctly for the answer in the margin space
Draw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(20x1=20)
The Answers to MCQ questions (Q.No. i to Q.No. xx) shall be written continuously on the first two
Read the following clinical history and select the most appropriate response for questions (i) -(v)
A 7 year old girl presented with swollen red tender joints which migrate from one joint to the other (knees,
ankles, hips and elbows) over a period of hours. She also complained of painless lumps beneath the skin
overlying bony prominences. She had shortness of breath and on auscultation, murmur was heard over mitral
episodes of sore throat over a period of 1 year, the last one being 3 weeks back.
i. The probable clinical diagnosis is
a) Endocarditis
c) Rheumatic heart disease
d) Mitral valve prolapse
ii. The etiological agent in the above diagnosis is
a) Streptococcus pyogenes
c) Staphylococcus aureus
d) Staphylococcus epidermidis
iii. The serological test used for this condition is
a) Coagulase test
c) Bacitracin test
d) Antiphosphatase test
iv. Recurrence of such episodes as in this case can be prevented by prophylaxis with
a) Vancomycin
b) Methicillin
d) Penicillin
v. In the above question, antibiotic treatment should be continued for
a) 1 week
b) 4weeks
d) 5-10 years
Question numbers (vi)-(x) are multiple response type questions. Read the statements & mark the
answers appropriately.
vi. A marker of sepsis is
3) Serum lactate 4) Low hemoglobin
a) 1, 2, 3 are correct b) 1, 3, 4 are correct c) 2, 3, 4 are correct d) 1, 2, 4 are correct
vii. Western blot test for HIV
1) is a supplemental test
3) Detects antibodies against HIV
4) is based on immunoblotting technique
a) 1, 2, 3 are correct b) 1, 2, 4 are correct
c) 1, 3, 4 are correct d) 2, 3, 4 are correct
1) Trypomastigotes in bone marrow
2) LD bodies in bone marrow
3) Amastigotes in skin smears
4) Trypomastigotes in peripheral blood
c) 1, 3, 4 are correct d) 1, 2, 4 are correct
ix. Diethylcarbamazine provocation test is NOT done for
1) Chagas disease 2) Trypanosomiasis
3) Lymphatic filariasis 4) Leishmaniasis
c) 1, 3, 4 are correct d) 1, 2, 4 are correct
x. Cutaneous wound infections NOT caused by
1) Vibrio cholerae
2) Vibrio fluvialis
a) 1, 2, 4 are correct b) 1, 3, 4 are correct
c) 2, 3, 4 are correct d) 1, 2, 3 are correct
Question numbers (xi) ? (xv) are single response types
xi. Which of the following can be used to cultivate viruses
b) Thioglycollate broth
c) Tissue culture d) Stuart's medium
xii. Fungal filament in skin scrapings can be visualized after digestion using
a) KOH
c) KCl
d) NaCl
xiii. Gram negative bacteria are inherently resistant to
a) Vancomycin
c) Netilmicin
d) Tobramycin
(PTO)
a) rRNA
b) DNA
c) Plasmid
d) mRNA
a) Autograft
b) Isograft
c) Allograft
d) Xenograft
questions by selecting the appropriate options given below.
xvi. A: T lymphocytes confer innate immunity.
R: Dendritic cells act as antigen presenting cells.
a) Both A and R are true, and R is the correct explanation of A
b) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
xvii. A: Tumor marker used for the diagnosis of Hepatocellular carcinoma in adult is alpha fetoprotein.
R: Alpha fetoprotein is a protein expressed on normal cells in fetal life but not in adult life normally;
a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
R: Helper T lymphocytes help B lymphocytes make antibodies
a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A
xix. A: Window period in HIV infection is from entry of virus to appearance of symptoms.
R: Guidelines for HIV testing in India have been laid down by National AIDS Control Organisation.
a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
d) A is false but R is true
xx. A: Culture negative endocarditis is seen in infection caused by Coxiella burnetti.
R: All culture negative endocarditis are due to prior antibiotic exposure.
a) Both A and R are true, and R is the correct explanation of A
b) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
Essays
2. A 20 year old male develops redness and swelling over the skin after eating peanuts.
a) Define and classify hypersensitivity
.
b) What is the type of hypersensitivity reaction seen in the above case.
.
d)
Enumerate the clinical manifestations of this type of hypersensitivity and its management.
e) Enumerate the clinical applications of this type of hypersensitivity with two suitable examples
(3+1+3+1+2
)
3. A 45 year old male presented in dermatology OPD with history of an itchy annular lesion over the scalp for
the past 20 days, which on examination looked like a fungal infection.
s.
b) What are the appropriate samples to be collected in the above case
.
c) Describe, in detail, the laboratory tests that must be done to reach a diagnosi
d) Enumerate three clinical types of superficial mycoses and their causative agent
(1+1+5+3
)
Short Essay
(6X6=36)
4. Central Sterile Supplies Department (CSSD) ? draw a schematic diagram of layout and workflow
5. Discuss various mechanisms of autoimmunity.
x differences between active and passive immunity.
7. Classify types of vaccines with one example each. Discuss advantages and disadvantages of different
types of vaccines.
(2+4
8. What is an antibiogram. How is it useful in a hospital.
(2+4)
9
. What is virulence
(1+ 3+2
)
Short Answer
s
(6x4=24
)
10. List 4 disinfectants with respective application in the hospital
.
.
12. List one viral, bacterial, fungal, parasitic opportunistic infection seen in AIDS patients
.
13. List four modes of transmission of infection, with one example each
14. Enumerate the agents causing enteric fever. Name the serological test indicated for the above condition.
In which week of illness should the test be done
. What is the gold standard method for diagnosis and in
which week of illness is it highly sensitive
)
15. Define Feve
r of Unknown Origin (FUO). List six causes of FUO commonly seen in India. (1+3
)
*
Q.P. Code: 215001
Reg. no.: .....................
Second Professional MBBS Degree Regular/Supplementary Examinations
December 2024
--- Content provided by FirstRanker.com ---
Microbiology Paper ITime: 3 Hours
Total Marks: 100
Answer all questions to the point neatly and legibly ? Do not leave any blank pages between answers
Indicate the question number correctly for the answer in the margin space
--- Content provided by FirstRanker.com ---
Answer all parts of a single question together ? Leave sufficient space between answersDraw table/diagrams/flow charts wherever necessary
1. Multiple Choice Questions
(20x1=20)
The Answers to MCQ questions (Q.No. i to Q.No. xx) shall be written continuously on the first two
--- Content provided by FirstRanker.com ---
writing sheets (ie Page No. 3 & 4) onlyRead the following clinical history and select the most appropriate response for questions (i) -(v)
A 7 year old girl presented with swollen red tender joints which migrate from one joint to the other (knees,
ankles, hips and elbows) over a period of hours. She also complained of painless lumps beneath the skin
overlying bony prominences. She had shortness of breath and on auscultation, murmur was heard over mitral
--- Content provided by FirstRanker.com ---
valve area. ECG showed prolonged P-R interval. On enquiry, it was found that the child had repeatedepisodes of sore throat over a period of 1 year, the last one being 3 weeks back.
i. The probable clinical diagnosis is
a) Endocarditis
c) Rheumatic heart disease
--- Content provided by FirstRanker.com ---
b) Functional mitral regurgitationd) Mitral valve prolapse
ii. The etiological agent in the above diagnosis is
a) Streptococcus pyogenes
c) Staphylococcus aureus
--- Content provided by FirstRanker.com ---
b) Streptococcus agalactiaed) Staphylococcus epidermidis
iii. The serological test used for this condition is
a) Coagulase test
c) Bacitracin test
--- Content provided by FirstRanker.com ---
b) Anti Streptolysin O testd) Antiphosphatase test
iv. Recurrence of such episodes as in this case can be prevented by prophylaxis with
a) Vancomycin
b) Methicillin
--- Content provided by FirstRanker.com ---
c) Cloxacillind) Penicillin
v. In the above question, antibiotic treatment should be continued for
a) 1 week
b) 4weeks
--- Content provided by FirstRanker.com ---
c) 1 yeard) 5-10 years
Question numbers (vi)-(x) are multiple response type questions. Read the statements & mark the
answers appropriately.
vi. A marker of sepsis is
--- Content provided by FirstRanker.com ---
1) C reactive protein 2) Procalcitonin3) Serum lactate 4) Low hemoglobin
a) 1, 2, 3 are correct b) 1, 3, 4 are correct c) 2, 3, 4 are correct d) 1, 2, 4 are correct
vii. Western blot test for HIV
1) is a supplemental test
--- Content provided by FirstRanker.com ---
2) Is a confirmatory test as it detects antigens of HIV3) Detects antibodies against HIV
4) is based on immunoblotting technique
a) 1, 2, 3 are correct b) 1, 2, 4 are correct
c) 1, 3, 4 are correct d) 2, 3, 4 are correct
--- Content provided by FirstRanker.com ---
viii. A fact NOT pathognomonic of visceral Leishmaniasis is1) Trypomastigotes in bone marrow
2) LD bodies in bone marrow
3) Amastigotes in skin smears
4) Trypomastigotes in peripheral blood
--- Content provided by FirstRanker.com ---
a) 1, 2, 3 are correct b) 2, 3, 4 are correctc) 1, 3, 4 are correct d) 1, 2, 4 are correct
ix. Diethylcarbamazine provocation test is NOT done for
1) Chagas disease 2) Trypanosomiasis
3) Lymphatic filariasis 4) Leishmaniasis
--- Content provided by FirstRanker.com ---
a) 2, 3, 4 are correct b) 1, 2, 3 are correctc) 1, 3, 4 are correct d) 1, 2, 4 are correct
x. Cutaneous wound infections NOT caused by
1) Vibrio cholerae
2) Vibrio fluvialis
--- Content provided by FirstRanker.com ---
3) Vibrio mimicus 4) Vibrio vulnificusa) 1, 2, 4 are correct b) 1, 3, 4 are correct
c) 2, 3, 4 are correct d) 1, 2, 3 are correct
Question numbers (xi) ? (xv) are single response types
xi. Which of the following can be used to cultivate viruses
--- Content provided by FirstRanker.com ---
a) Blood agarb) Thioglycollate broth
c) Tissue culture d) Stuart's medium
xii. Fungal filament in skin scrapings can be visualized after digestion using
a) KOH
--- Content provided by FirstRanker.com ---
b) NaOHc) KCl
d) NaCl
xiii. Gram negative bacteria are inherently resistant to
a) Vancomycin
--- Content provided by FirstRanker.com ---
b) Gentamicinc) Netilmicin
d) Tobramycin
(PTO)
--- Content provided by FirstRanker.com ---
xiv. An example of extrachromosomal element isa) rRNA
b) DNA
c) Plasmid
d) mRNA
--- Content provided by FirstRanker.com ---
xv. Tissue transplantation between identical twins is an example ofa) Autograft
b) Isograft
c) Allograft
d) Xenograft
--- Content provided by FirstRanker.com ---
Question numbers (xvi) ? (xx) consists of two Statements-Assertion (A) and reason (R). Answer thesequestions by selecting the appropriate options given below.
xvi. A: T lymphocytes confer innate immunity.
R: Dendritic cells act as antigen presenting cells.
a) Both A and R are true, and R is the correct explanation of A
--- Content provided by FirstRanker.com ---
c) A is true but R is falseb) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
xvii. A: Tumor marker used for the diagnosis of Hepatocellular carcinoma in adult is alpha fetoprotein.
R: Alpha fetoprotein is a protein expressed on normal cells in fetal life but not in adult life normally;
--- Content provided by FirstRanker.com ---
exponentially high levels in tumor cells.a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
--- Content provided by FirstRanker.com ---
xviii. A: B lymphocytes have immunological memory.R: Helper T lymphocytes help B lymphocytes make antibodies
a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
b) Both A and R are true, and R is not the correct explanation of A
--- Content provided by FirstRanker.com ---
d) A is false but R is truexix. A: Window period in HIV infection is from entry of virus to appearance of symptoms.
R: Guidelines for HIV testing in India have been laid down by National AIDS Control Organisation.
a) Both A and R are true, and R is the correct explanation of A
c) A is true but R is false
--- Content provided by FirstRanker.com ---
b) Both A and R are true, and R is not the correct explanation of Ad) A is false but R is true
xx. A: Culture negative endocarditis is seen in infection caused by Coxiella burnetti.
R: All culture negative endocarditis are due to prior antibiotic exposure.
a) Both A and R are true, and R is the correct explanation of A
--- Content provided by FirstRanker.com ---
c) A is true but R is falseb) Both A and R are true, and R is not the correct explanation of A
d) A is false but R is true
Essays
--- Content provided by FirstRanker.com ---
(2x10=20)2. A 20 year old male develops redness and swelling over the skin after eating peanuts.
a) Define and classify hypersensitivity
.
b) What is the type of hypersensitivity reaction seen in the above case.
--- Content provided by FirstRanker.com ---
c) Describe the mechanism.
d)
Enumerate the clinical manifestations of this type of hypersensitivity and its management.
e) Enumerate the clinical applications of this type of hypersensitivity with two suitable examples
--- Content provided by FirstRanker.com ---
.(3+1+3+1+2
)
3. A 45 year old male presented in dermatology OPD with history of an itchy annular lesion over the scalp for
the past 20 days, which on examination looked like a fungal infection.
--- Content provided by FirstRanker.com ---
a) What is the probable clinical diagnosis.
b) What are the appropriate samples to be collected in the above case
.
c) Describe, in detail, the laboratory tests that must be done to reach a diagnosi
--- Content provided by FirstRanker.com ---
s.d) Enumerate three clinical types of superficial mycoses and their causative agent
(1+1+5+3
)
Short Essay
--- Content provided by FirstRanker.com ---
s(6X6=36)
4. Central Sterile Supplies Department (CSSD) ? draw a schematic diagram of layout and workflow
5. Discuss various mechanisms of autoimmunity.
--- Content provided by FirstRanker.com ---
6. State six differences between active and passive immunity.
7. Classify types of vaccines with one example each. Discuss advantages and disadvantages of different
types of vaccines.
(2+4
--- Content provided by FirstRanker.com ---
)8. What is an antibiogram. How is it useful in a hospital.
(2+4)
9
. What is virulence
--- Content provided by FirstRanker.com ---
. List the different mechanisms of virulence in bacteria. Explain one of them in detail.(1+ 3+2
)
Short Answer
s
--- Content provided by FirstRanker.com ---
(6x4=24
)
10. List 4 disinfectants with respective application in the hospital
.
--- Content provided by FirstRanker.com ---
11. How will you advise a health care worker to avoid needle stick injury while collecting blood from patients.
12. List one viral, bacterial, fungal, parasitic opportunistic infection seen in AIDS patients
.
13. List four modes of transmission of infection, with one example each
--- Content provided by FirstRanker.com ---
.14. Enumerate the agents causing enteric fever. Name the serological test indicated for the above condition.
In which week of illness should the test be done
. What is the gold standard method for diagnosis and in
which week of illness is it highly sensitive
--- Content provided by FirstRanker.com ---
. (1+1+1+0.5 +0.5)
15. Define Feve
r of Unknown Origin (FUO). List six causes of FUO commonly seen in India. (1+3
)
--- Content provided by FirstRanker.com ---
***************************