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QUESTION BANK- CLINICAL TOXICOLOGY
IV PHARM.D
CHAPTER 1 : General principles involved in the management of poisoning 3 hrs
| II SHORT ESSAYS: | 5 Marks |
- Explain ABCD management of Poisons?
--- Content provided by FirstRanker.com --- - Write the grading for the severity of CNS intoxication?
- Write briefly on Acid-base disorders and its causes?
- Explain in detail general principles involved in the management of poisoning?
- Explain in detail the stabilization and evaluation in the management of poisoning.
- Explain briefly Glasgow coma Scale.
--- Content provided by FirstRanker.com --- - Explain the role of Sodium bicarbonate in the management of poisoning?
- Explain the electrolyte disturbance in poisoning?
- Mention the drugs associated with pulse rate and blood pressure?
- Add a note on toxic syndromes.
- Explain toxic ophthalmological manifestations?
--- Content provided by FirstRanker.com --- - Discuss the dermal manifestation of poisoning.
- Mention the poison/ drug induced oral manifestations
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| III SHORT ANSWER: | 2 Marks |
- Define Fluminant, Acute, Subacute and Chronic poisoning.
- Mention the Toxicity rating of poisons.
- Mention the Poisoning severity score for acute poisoning.
--- Content provided by FirstRanker.com --- - Define UFD and MLD.
- Discuss the methods of preventing absorption of poisons.
- Mention the Drug / toxin induced arrhythmias.
- List the drugs causing non-cardiogenic pulmonary oedema.
- Management of hyperthermia.
--- Content provided by FirstRanker.com --- - Management of hypothermia.
- What is Coma cocktail?
- List the drugs that induces tremor.
- Management of tremor in poisoning.
- Mention the drugs that cause movement disorders.
--- Content provided by FirstRanker.com --- - Give two examples for Drugs / poison which cause papillary changes (Miosis, Mydriasis and Nystagmus) for each.
- Mention two drugs which cause failure of respiratory centre and respiratory muscle.
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- Give examples of drugs / toxins that cause acute renal failure.
- Write the examples of drugs / toxins that cause hepatic damage?
--- Content provided by FirstRanker.com --- - Explain role of emesis in acute poisoning.
- Mention the importance of bowel irrigation in poisoning.
- Explain the role of chelating agents in acute poisoning.
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CHAPTER 2: Antidotes and the clinical applications 2 hrs
| III SHORT ANSWER: | 2 Marks |
- Define and classify antidotes.
--- Content provided by FirstRanker.com --- - Explain the role of antidote in poisoning.
- Write a short note on antidotes and give examples with their clinical application?
- Explain Accelerated detoxification and reduced toxic conversion antidote with examples.
- Write the composition of Universal antidote?
- Define Adjunctival antidotes with example.
--- Content provided by FirstRanker.com --- - Define and mention the composition of obsolete antidote.
- Explain toxic effect bypass antidote action with example?
- Explain receptor site competition antidote action with example?
- Explain receptor blockade antidote action with example?
- Add a note on inert complex formation antidote action with example.
--- Content provided by FirstRanker.com --- - Antidotes used in methanol poisoning.
- List the modes of action of antidotes.
- Name the specific antidotes for the following
- Paracetamol
- Organophosphorus compounds
- Iron
--- Content provided by FirstRanker.com --- - Morphine
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CHAPTER 3: Supportive care in clinical Toxicology 3 hrs
| II SHORT ESSAYS: | 5 Marks |
- Give a short note on role of supportive care measures in poisoning.
- Describe the role of basic supportive care in the management of poisoning?
--- Content provided by FirstRanker.com --- - Discuss the supportive care for Airway correction.
- Explain the supportive care for breathing correction.
- Explain the supportive care for Circulation correction.
- Write a note on supportive care in clinical toxicology?
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- Write the importance of electrolytes as a supportive care in poisoning?
- Explain the importance of supportive care in clinical toxicology.
- Explain the supportive care to treat Sedation.
- Explain the supportive care to treat seizure.
- Explain the supportive care for restoration of renal function.
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CHAPTER 4: Gut Decontamination 3 hrs
| SHORT ESSAYS: | 5 marks |
- Describe the technique, contraindication, potential complication and adverse effect of emesis method of gut decontamination.
- Explain the different methods of gut decontamination.
- Explain the general principles of gut decontamination with advantages and disadvantages.
- Write the techniques, indications, contraindications and complications involved in gastric lavage.
--- Content provided by FirstRanker.com --- - Discuss the technique, contraindication, potential complication and adverse effect of Activated charcoal method of gut decontamination.
- Explain the role of gastric lavage and charcoal administration in Gut decontamination process.
- Explain the technique, contraindication, potential complication and adverse effect of cathartics method of gut decontamination.
- Explain the technique, contraindication, potential complication and adverse effect of whole- bowel irrigation method of gut decontamination.
- Add a note on gastrointestinal decontamination risk-benefit analysis.
--- Content provided by FirstRanker.com --- - Explain the Oral binding agents in gut decontamination
- List out the Gut decontamination methods.
- Enumerate the contraindications in gastric lavage.
- Write the gastrointestinal decontamination triangle?
- Mention the complications of emesis in gut decontamination.
--- Content provided by FirstRanker.com --- - Disadvantages of Gut Decontamination
- Multiple dose activated charcoal.
- Uses of light kaolin and charcoal in poisoning.
- Describe the mechanism and uses of EDTA in clinical toxicology.
- List the complications of gastric lavage in gut decontamination.
--- Content provided by FirstRanker.com --- - Write the complications of Activated charcoal in gut decontamination?
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- Mention the complications of cathartics in gut decontamination.
- Write the complications of whole-bowel irrigation in gut decontamination?
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CHAPTER 5: Elimination Enhancement. 2 hrs
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| III SHORT ANSWER: | 2 Marks |
- Write the elimination enhancement methods in treatments of acute poisoning.
- Mention urinary alkalisation method of elimination enhancement of poisons.
- Write the potential complication and indication of urinary alkalisation method of elimination enhancement of poisons.
- Write the importance of multiple doses of activated charcoal in elimination enhancement technique
- What is extracorporeal techniques in elimination of poisons
--- Content provided by FirstRanker.com --- - Write a the role of dialysis in elimination enhancement of poisons?
- Explain the role of hemodialysis in the management of poisoning.
- Define a) Hemoperfusion b) Haemodialysis c) Plasmapheresis d) Hemodiafiltration
- Write the advantages and disadvantages of Hemoperfusion in elimination enhancement of poisons.
- Write the significances of Haemodialysis in elimination enhancement of poisons?
--- Content provided by FirstRanker.com --- - What is Plasmapheresis? Mention its role in elimination enhancement of poisons?
- Write the potential complications of multiple doses of activated charcoal technique for elimination of poisons?
- Expand CAVHD, write its significance.
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CHAPTER 6: Toxicokinetics 2 hrs
| III SHORT ANSWER: | 2 Marks |
- Define and enlist the various parameters of toxicokinetics.
--- Content provided by FirstRanker.com --- - Define toxicokinetics and write its importance.
- Write the clinical Applications of toxicokinetics?
- Mention the toxicokinetic studies.
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- Write the toxicokinetics of paracetamol
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CHAPTER 7 : Clinical symptoms and management of acute poisoning of:
a). Pesticide poisoning: Organophosphorous compounds, carbamates, organochlorines, pyrethroids,
b) Opiates overdose c) Antidepressants, d) Barbiturates and benzodiazepines, e) Alcohol: ethanol, methanol, f) Paracetamol and salicylates, g) Non-steroidal anti-inflammatory drugs, h)Hydrocarbons: Petroleum products and PEG. i) Caustics: inorganic acids and alkali, j). Radiation poisoning
| I LONG ESSAYS: | 16 hrs 10 Marks |
- What are the signs and symptoms of acute poisoning with organophosphorus compounds? Describe its clinical management.
- Explain the signs and symptoms and management of organochlorine poisoning.
--- Content provided by FirstRanker.com --- - Enlist the various pesticides and explain the clinical symptoms and management of acute poisoning of any two.
- Classify Pyrethroids. Explain the management of Pyrethroid poisoning.
- What are signs and symptoms of opiates poisoning and its management?
- Explain the clinical symptoms and management of acute poisoning with barbiturates and benzodiazpines.
- Define and classify the antidepressants and explain the clinical symptoms and management of acute poisoning of tricyclic anti-depressants
--- Content provided by FirstRanker.com --- - Explain in details about the management of acute poisoning with ethanol and methanol.
- Explain signs and symptoms and management of Paracetamol, NSAID and salicylates.
- Discuss the acute poisoning with hydrocarbons.
- Define and classify caustics? Explain clinical features and management of acute poisoning with inorganic acids and alkali.
- Describe the clinical symptoms and management of radiation poisoning.
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| II SHORT ESSAYS: | 5 Marks |
- Write a note on management of organophosphorus poisoning?
- Mention the clinical features and management of carbamate poisoning.
- Explain the management of opiate poisoning.
- Write the clinical symptoms and management of TCA?
- Discuss on barbiturate overdose and its management.
--- Content provided by FirstRanker.com --- - Discuss the clinical symptoms and treatment of acute poisoning with Barbiturates.
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- Explain the clinical symptoms and treatment of acute poisoning with BZD.
- Explain briefly clinical features and management of acute poisoning with ethanol.
- Briefly explain clinical features and management of acute poisoning with methanol.
--- Content provided by FirstRanker.com --- - Write the manifestation of alcohol withdrawal syndrome?
- Explain the clinical symptoms and management of acute poisoning with paracetamol overdose.
- Explain the clinical symptoms and management of acute poisoning with aspirin.
- Explain the clinical symptoms and management of acute poisoning with salicylates.
- Discuss the nephrotoxicity of NSAIDs.
--- Content provided by FirstRanker.com --- - Explain briefly clinical features and management of acute poisoning with inorganic acids and alkali.
- Explain the clinical symptoms and management of acute poisoning with hydrocarbons.
- Enumerate the clinical symptoms and management of acute poisoning with radiation poisoning.
- Explain the clinical symptoms and complications of radiation poisoning.
- Explain the hepatotoxicity of paracetamol.
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| III SHORT ANSWER: | 2 Marks |
- Clinical effects of organophosphorous poisoning.
- Write the role of atropine in OP poisoning?
- Classify OP Compounds.
- Classify pyrethroid pesticides with examples.
- Mention the importance of PAM(Pralidoxime) in OP poisoning
--- Content provided by FirstRanker.com --- - Write the usual fatal dose of Morphine?
- Mention the signs and symptoms of Opiates overdose.
- Write the signs and symptoms of MAOI acute poisoning?
- List out the Opioid antagonists
- Toxicity of petroleum products
--- Content provided by FirstRanker.com --- - Management of NSAIDS poisoning.
- Explain management of salicylates poisoning.
- Explain signs and symptoms of organochlorine poisoning.
- Management of benzodiazepines poisoning.
- signs and symptoms of Inorganic acid poisoning.
--- Content provided by FirstRanker.com --- - Clinical effect of methanol poisoning.
- What are the clinical symptoms of hydrocarbon poisoning?
- Clinical symptoms of radiation poisoning.
- Management of acute poisoning with inorganic acids.
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- Signs and symptoms of paracetamol poisoning.
- Treatment for acute methanol poisoning.
- Alcohol withdrawal syndrome.
- Clinical symptoms of barbiturate poisoning.
- Signs and symptoms of poisoning with PEG.
--- Content provided by FirstRanker.com --- - Clinical symptoms of salicylism.
- Signs and symptoms of acid injury.
- Clinical effects of poisoning with inorganic acids.
- Clinical symptoms of radiation poisoning.
- Clinical symptoms of antidepressant poisoning.
--- Content provided by FirstRanker.com --- - Paraquet toxicity.
- Write the Treatment for Reye's syndrome.
- What is Rumack matthew nomogram?
- Stages of Acute Radiation Syndrome
- Biological effects of ultraviolet radiation
--- Content provided by FirstRanker.com --- - Sources of non ioninzing radiation
- Mode of action of alkali poisoning
- Treatment of alkali poisoning
- Treatment of sulfuric acid poisoning
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CHAPTER 8: Clinical symptoms and management of chronic poisoning with the following agents- Heavy metals: Arsenic, lead, mercury, iron, copper 6 hrs
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| I LONG ESSAYS: | 10 Marks |
- Describe the clinical symptoms and management of chronic poisoning with the heavy metals.
- Discuss the clinical symptoms and management of chronic poisoning with arsenic and lead.
- Describe the clinical symptoms and management of chronic poisoning with iron, mercury and copper.
- Discuss various heavy metal poisoning emphasizing the clinical symptoms and its management.
- Enumerate the clinical symptoms, laboratory tests and management of chronic poisoning with Lead.
--- Content provided by FirstRanker.com --- - Write a note on the general principles in the management of heavy metals poisoning?
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| III SHORT ANSWER: | 2 Marks |
- Mention the application of deferoxamine.
- Enlist the application of chelating agents in heavy metal poisoning.
- Write the laboratory test used for diagnosing lead poisoning?
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- Expand the BAL and DMSA.
- Explain the clinical features of copper sulphate poisoning.
- Discuss the various laboratory test used for diagnosing lead poisoning.
- Write the signs and symptoms of arsenic poisoning?
- Write the clinical effect of poisoning with mercury?
--- Content provided by FirstRanker.com --- - Explain the management of iron poisoning.
- Write the Antidote for mercury poisoning?
- Enlist the treatment options for mercury poisoning.
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CHAPTER 9: Venomous snake bites: Clinical effects of venoms, general management as first aid, early manifestations, complications and snake bite injuries 4 hrs
| II SHORT ESSAYS: | 5 Marks |
- Describe the signs and symptoms of venomous snake bite and its management.
--- Content provided by FirstRanker.com --- - Describe the Clinical effects of Venom, general first aid management for snake bite injuries?
- Write a short note clinical effect of snake venoms?
- Write the early manifestations, complications and management of snake bite injuries?
- Enlist the signs, symptoms and treatment of snakebite poisoning.
- Write the general first aid management for snake bite?
--- Content provided by FirstRanker.com --- - Classify the venomous snakes with examples.
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| III SHORT ANSWER: | 2 Marks |
- Write the differences between venomous and non- venomous snakes?
- What is ASV?
- Classify different type of venomous snakes.
- Signs and symptoms of snake poisoning.
--- Content provided by FirstRanker.com --- - First aid measures for snake bite.
- Distinguish between venomous and non-venomous snake bite.
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CHAPTER 10: Plants poisoning- Clinical symptoms and management of Mushrooms, Mycotoxins 2 hrs
| III SHORT ANSWER: | 2 Marks |
- Add a note on Mycotoxins poisoning.
- Write the management of Mycotoxins poisoning
--- Content provided by FirstRanker.com --- - Write the clinical symptoms of Mycotoxins poisoning
- What is the role of atropine in mushroom poisoning?
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- Discuss the clinical features of mushroom poisoning.
- Write the management of poisoning with mushrooms.
--- Content provided by FirstRanker.com --- - Short note on aflatoxin.
- Name toxic mushroom.
- Classify the mushrooms with examples.
- Name the poisonous mushrooms.
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CHAPTER 11: Food Poisonings- Clinical symptoms and management of Food Poisonings 2 hrs
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| III SHORT ANSWER: | 2 Marks |
- Give the complications of food poisoning.
- Give the sources of food poisoning.
- Write about shell fish poisoning
- Management of microbial food poisoning.
- Write on etiology of food poisoning
--- Content provided by FirstRanker.com --- - Mention the importance of ORT in food poisoning
- Write the general treatment measures for food poisoning
- Write the significance of IV rehydration therapy in food poisoning.
- Write nonspecific anti diarrhoeal agents used in food poisoning.
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CHAPTER 12: Envenomations- Clinical symptoms and management of Arthropod bites and stings 2hrs
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| III SHORT ANSWER: | 2 Marks |
- What are the Clinical effects of arthropod bites and stings?
- Write the management for Arthropods bite.
- Discuss the management of scorpion bite.
- Write the signs and symptoms and first aid for scorpion bite?
- First aid of arthropod bites.
--- Content provided by FirstRanker.com --- - Write the signs and symptoms of wasp bite
- Write the treatment of Bee bite
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CHAPTER 13: Substance abuse- Signs and symptoms of substance abuse and treatment of dependence a) CNS stimulants: Amphetamine, b) Opioids, c) CNS depressants, d) Hallucinogens: LSD, e) Cannabis group, f) Tobacco 3 hrs
| II SHORT ESSAYS: | 5 Marks |
- Enumerate the signs and symptoms of substance abuse and treatment of dependence with amphetamine
- What are the signs and symptoms and treatment of opioid dependence?
--- Content provided by FirstRanker.com --- - Write the clinical features and management of substance abuse of CNS depressants?
- Explain the clinical symptoms and management of cannabis dependence?
- Discuss the clinical symptoms and management of hallucinogens and tobacco abuse.
- Diazepam substance abuse.
- Describe the Abuse potential of amphetamine.
--- Content provided by FirstRanker.com --- - Discuss the DSM-IV criteria for substance abuse.
- Explain the management of cocaine detoxification.
- Mention the role of nicotine therapy in smoking cessation.
- Short note on tobacco dependence.
- Explain the hallucinogenic drug abuse.
--- Content provided by FirstRanker.com --- - List down the symptoms of cannabis abuse and its treatment.
- Explain the signs and symptoms of substance abuse and treatment of opioid dependence.
- Explain the signs and symptoms of substance abuse and management of dependence with amphetamine.
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