Download MBBS RUHS 1st Year 1st Year 2023 January Biochemistry Paper I Question Paper

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25-01-2023

I-MBBS (Part-I)

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04113 A1 + 01113 A2

(This question paper consists of 2 pages)

First M.B.B.S. (Main) Examination (New Scheme)

January – 2023

Biochemistry

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Paper- I

Time: Three Hours

Maximum Marks: 100

Attempt all questions in both sections.

Section-A

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1. Fill in the blanks: 6x1=06
   1. Lipoprotein responsible for reverse cholesterol transport is __________.
   2. Secondary structure present in collagen protein __________.
   3. Low Km value indicates __________ affinity between enzyme and substrate.
   4. Chemical name of calcitriol is __________.
   5. Nitric oxide is synthesized from __________ amino acid.

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   6. Type of bilirubin increased in obstructive jaundice is __________.
2. Choose the correct option in the following multiple choice questions: 4x1=4
   1. Which type of inhibition warfarin has on vitamin K dependent carboxylase?
      1. Competitive
      2. Non-competitive
      3. Allosteric

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      4. Suicidal
   2. Polysaccharide does not give colour with iodine test:
      1. Starch
      2. Dextrin
      3. Cellulose

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      4. Glycogen
   3. Von -Gierke's disease is characterised by all except:
      1. Lactic acidosis
      2. Hyperglycemia
      3. Hyper uricemia

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      4. Hyperlipidemia
   4. Complex of electron transport chain not functions as proton pump:
      1. Complex I
      2. Complex II
      3. Complex III

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      4. Complex IV
3. A 66-year-old obese male had severe chest pain in the morning after doing exercise. He described pain as retrosternal and radiating to the left arm. On investigation, serum troponin I was raised. He had complaints of dyspnoea and intermittent palpitations. Based on this history, answer: 5x3=15
   1. What is the probable diagnosis?
   2. What other investigations are to be performed for diagnosis?

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   3. What is the role of isoenzymes in the diagnosis of this case?
   4. What is a flipped pattern?
   5. What are various risk factors for this disease?
4. Write short notes on (Any Five): 5x2=10
   1. Ferritin

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   2. Anion gap
   3. Atherosclerosis
   4. Uncouplers
   5. Denaturation of proteins
   6. Transaminases

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5. Explain briefly (Any Three): 3x5=15
   1. Chemiosmotic theory
   2. Krebs-Henseleit cycle
   3. Fates of Acetyl CoA
   4. Functions of electrolytes

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Section-B

6. Discuss the reactions of Krebs cycle with its energetics. Suggest role of vitamins in Krebs cycle. 20
7. Explain Why (Any Five): 5x2=10
   1. Liver cannot utilize ketone bodies.
   2. Insulin is given to diabetics by subcutaneous route.

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   3. Eating raw eggs causes biotin deficiency.
   4. Vitamin C is not synthesized in humans.
   5. Ketoacidosis is observed in starvation.
   6. Ammonia is toxic to brain.

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8. Explain briefly (Any Four): 4x5=20
   1. Products obtained from glycine amino acid
   2. Biochemical functions and deficiency manifestations of Vitamin A
   3. Diagnostic significance of enzymes
   4. Differential diagnosis of jaundice
   5. Gluconeogenesis

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