Download MBBS RUHS 1st Year 1st Year 2023 November Biochemistry Paper I Question Paper

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20-11-2023

I-MBBS 01113A1+01113A2

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(This question paper consists of 2 pages)

First M.B.B.S. (New Scheme) (Main) Examination

November - 2023

Biochemistry

Paper- I

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Time: Three Hours

Maximum Marks: 100

Attempt all questions in both sections.

(Use separate answer book for each section)

Section-A

1. Fill in the blanks: 6x1=06
   1. Monosaccharide which causes sequestering of phosphate in the cell __________.

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   2. Phenylpyruvic acid in urine is detected by __________.
   3. Ferrochelatase is deficient in __________ condition.
   4. Lysine is a limiting amino acid in __________ food.
   5. Vitamin E acts synergistically with __________ ion.

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2. Choose the correct option in the following multiple choice questions: 5x1=5
   1. Phospholipid deficient in newborn suffering from respiratory distress syndrome.
      1. Phosphatidylethanolamine
      2. Phosphatidylcholine
      3. Phosphatidylserine
      4. Cardiolipin

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   2. Folate reductase is inhibited by drug.
      1. Erythromycin
      2. Chloramphenicol
      3. Methotrexate
      4. 5-Fluorouracil

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   3. Effect of thromboxane is.
      1. Increase in platelet aggregation
      2. Relaxation of smooth muscle
      3. Decrease in blood pressure
      4. Produces vasodilation

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   4. Following congenital disease is associated with conjugated hyperbilirubinemia.
      1. Crigler-Najjar syndrome
      2. Gilbert's disease
      3. Dubin-Johnson syndrome
      4. Congenital spherocytosis

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   5. All of the following amino acids contribute to purine synthesis EXCEPT.
      1. Glycine
      2. Cysteine
      3. Glutamine
      4. Aspartate

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3. Clinical Case study: A six-month-old infant began to vomit occasionally and ceased to gain weight. At 9 months of age, he was admitted to the hospital. He was drowsy, with fever, hepatomegaly, and failure to feed.
   Urine analysis revealed a high amount of glutamine and uracil. Blood investigations showed absence of urea. EEG was grossly abnormal.
   1. What is the most probable diagnosis? 03
   2. Why are glutamine & uracil elevated? 04
   3. What is the cause of brain involvement in this patient? 04

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   4. What can be the treatment modality? 04
4. Differentiate between (Any five): 5x2=10
   1. Proteoglycans & Glycoproteins
   2. G-6-PD & G-6-Phosphatase
   3. Pre-hepatic and post-hepatic Jaundice

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   4. Haemoglobin & Myoglobin
   5. Carnitine & Creatine
   6. Uncompetitive & Non-competitive Inhibition
5. Explain briefly (Any three): 3x5=15
   1. Dehydration

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   2. Lipotropic factors
   3. Isoenzymes
   4. Orotic aciduria

Section-B

6. Describe the role of respiratory and renal regulation of pH. Add note on pH derangement due to diabetes. 20

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7. Explain Why (Any five): 5x2=10
   1. Vitamin B12 deficiency leads to folate trap.
   2. Patients of pancreatic insufficiency are advised to take medium and small chain fatty acids.
   3. Glucose uptake in intestine & kidney is called secondary active transport.
   4. Uronic acid pathway is important for detoxification of drugs.
   5. Carnitine deficiency leads to hypoglycaemia.

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   6. Arginine becomes semi-essential.
8. Explain briefly (Any four): 4x5=20
   1. Biologically active nucleotides & peptides
   2. Uncouplers
   3. Methionine metabolism

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   4. Niemann-Pick disease
   5. Mercury poisoning

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