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Download PG Medical 2nd Year Pharmacology Handwritten Notes

Download PG Medical ( Post Graduate Medical degree) 2nd Year Pharmacology Handwritten Notes

This post was last modified on 02 August 2021

Medical PG Handwritten Notes 1st Year, 2nd Year, 3rd Year and 4th Year (Study Material)


FR FirstRanker.com

Pharmacolology

Alims 2014.

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* PACLITAXEL is derived from ? genetic

Tacaves

Yew Trees.

Gene

Concentration

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CARRIER

ABSORPTION

pH of the

DRUG

(i) Acidec

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(ii) Basic

M/c Site of mionization ? STOMA

Mic site of Absorption ? Small

BIOPVAILABILITY:

(3) Anyphetanuice d

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unchanged avut of drug co

Systemic circulation

Depends on

(1) Amount of drug

(?) Frist pass Mete

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II.) DISTRIBUTION;

? Apparent Volume distribcition (Imagen

It is the total plasma

that is required for

TOTAL

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PLAS

total drug wi whole body

art total plauna Concarnation

UNIT OF VOLUME distribition ? LITR.

avd = D/C

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*D-Drug

*C-Concentr

? D: ?avdxc (specif

Rx ? Dialysin

* INFERENCE (?)

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(?) Irreversible binchi

a) organophospha

b) Carbamates.

C ? Cyclization

Q -> Hydrolysis

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D Aliphatic hydroxylation

Aromatie

D ?Deamination

(Allins.

PHASE I

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ToyPASO!

* CYP1A2 Lenclocus in particular

Family subfamily

* CYP286.

(pretabolise > 50% of dr

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I) PROTEASE INHIBITORS: (i)not only

(?) Enzyme inti

Max

RITONAVIR

II.) STAYTINS:

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?) (ALCIUM (HANNEL BLOCKERS

IV.) BENZODIAZEPINES

?) ESTROGEN/TESTOSTERONE

a.) 6 Mp

b) Methyldopa

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? SULFATION

a) Steroids

CYP3A4> CYBDb> CYP2C9 >

ADC

ABC.

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O.C.P

Failure

OCP Failure Caube also seen:

T) ANTIBIOTICS:

NORMAL

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Estrogen

Intabition of

Enterohepati

Circulation of

Enter Hepatri

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Estrogen.

Undulation

Soluble

Th

colon

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A

JRDE PLASMA (0)

Maintenance

Dase ? Rate

PLASINA Cond

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vd

RDG= D/vdx 0.

RDE DX 0.693

1/2

MAINTENANCE 0.693X

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DSC +

?200mg

100mg

7thao/20

180

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80mg H/2

160

andhon/20

bong

2

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3hm

15 110

bo

I)... As dose increases

1½ increases

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in Zero Ordo kucerin

I?) As dose increases

Clearance decreases.

(&HR)

RESPONSG

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50.

40-

30-

20-

10

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(ORC)

Efficacy)

? Dose

10 20 30 40 50

A (mg) B.

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? Potency.

SameEfficacy.

DRUG RECEPTOR INTERACTIONS;

THR 200/? F

A/HR/150/m² S

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31 = 70 H.R ?170 HR

No effec

50 HR OPPOS

HR? 40/min

g:

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GLUTAMATE

NMDA

AMPA

KAINATE

Gg :- NICOTINIC Receptors

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T?) G-PCR [ surpentine / 7 tretical]

[Metabotropic]

Two active Components

? GTPL

2

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? GDP &

POH

GTP (X

GTPase

?.

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GS

Adurylate Cyclare

?

1 Cyc AMP

?

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PKC

? Phospholipou

?

?PIP2

HIT

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* Random chemical Lining

LA

* DRUG LIBRARY

?

DRUG SCREENING

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?.) Rational Drug designing

(a) Structure Ligand

Based Boved

(i) Select the dis (HTN)

(ii) Study Pathophysw of

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RAASS FITN

(ii) Select a tangel (ACE)

(Fr) Determina Structure of targat C Cel

VACE

- 100,000 chemicals) (Dry

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Phase

JCP.C.S.E.Aguia

*. Committee for the purpo

of cxperiments in An

C.T [Humans)

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Make a protocol ? Submit to

T

Franker.cop Therapeuticonfimatory tract

wo of Ply)

? Replica of phase II i mere no

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Ra - Safety cup to 3000

Phare Efficacy Multicentri

? 1-5years

Eficacy of new drug is Compared t

In cave of Genericdrug

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?

Abbreviated New dre

*Centre for D

Bill?2009

2010

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?

* Alims

then

* Ghaziabad.

PHARMACO VIGILANCE

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pased med. colinges 42,

Hospitals

?

ADR

Report ADR Ea

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VIGIFLOW.

J.

[N.CC-PV]

Gro

1 Ipc build

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(N) health Volunteer

Samples Pk

P.D

PHASE ?:- [PharmaCoGpidemiology]

I) NCC.-P.Us (Ghazedabad [up]

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[Centre for drug

?.) CDSCO

?) IC-PV? International Centre for p

TV CARCT Central Drug Research &

Warfare

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TBM is not used in which drung:

? Drug & Lower Therapeuter Indu

NEET

"Therapeuti Index : (

?

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/ "Salty Bouga

Lithium

Theop

? Digoxin

Measure

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Potency,

Psy

Am

PHARMACO GENETICS PHARMACO GENOMI

Pharmacogenetics)

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* Effect of genes on

? Dose

drugs heves && Dose

?

Bring toxicity Receptors niy

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4)Fg. - CYP450 Polymorpture

* Cyp2519 Activation of clopidog

?

?

?

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• MI

?

• Astroke

Bleueming

PCarboxylation

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of Factor

?

Lidocarin

IT) PArgens polymorphing 12h/docaug

Particeprocess

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Coczt

2/

Cart

Cart

Cart

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RAR & TEYTY

[Malignau

Actieproces

Re: Daute

Daghashed

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P- Glycoprotein Inhibitors;

1.) Carinichie

2) Amiodarone

3) Verapamel (c)

4.) Cycledsporine

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5) Engthromycin

6) Itraconazole

ESSENTIAL DRUGS ?

a) Haloprid

b) Drafopam

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1) nopsture

First Ranker Leng Acti

(2) NK-10 Aprepitant

Aprepitant (2nd)

? Dronabind

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? C.BÐ?

Nabilone.

Corne Cells

Cove

(4) Metoclopramide Not only a D2 blocker

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[Damperidone

? Dexamethasone

* Parameter to be monitored in Cannabi

/ RIMONABANT

?

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Darr. Depression

(w)

Succedal

tendencies

(C) (Cu)

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CBIR

CB2R F

(C)

EB

4-hydroxy

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Cyclophosphamide

* Practure

?

Excreted

? Phospho

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? Mustar

(Actuje

Part)

4.

Cytoto

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B.) IFOSFAMIDE

?

Chloracetaldehyde

Neurotoxii/

?

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? GTCS

Ataxia

Coma.

?

ACROKEIN

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[Most Neurotoxic alkylating agent]

Doc:- Brow

* Temozolamide

S/E:: Pseudoprogression of Bre

TV MISCELLANEOUS DRUGS:

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* BUSULFAN:-

AML.

S/K ? Pulneoncory fibrosis

* BENDAMUSTINE:

use.- CLL

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No Cross resistance to other A..

S/E

NEPHROTOXIC

Tu

(C-cl

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Inactive

420

Picturepo

1.

Prevention

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Nad

* Preload & 1-2LN sakine

* Cisplatin+5%. D + Mannit

?

(Diveretie

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of chord

* Frisemidet cisplatin/X

Naurea

* Max < Vomiting

Must

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Pharmacokineties:.

Metabchum by Bleomycin hydray

Deficient

Lung

Slam -

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MITOMYCIN C:

MOA

? Toppisomerase D

?Free radical

A.A activity

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Toxic drung on Systemic

?.

TOPICAL

ANTHRACYCLINE groep

MOA:-

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Topoisomerase II

formation

Free Radical formation

?

Dependson

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Fe' atoms

Chelation

Defour aimin

S/E Cara

1

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Prece

Anti Folate Antica dru

METHOTREXATE

PEMETLEXED

* MOA DHFRE.

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Leucovorin +15 FU

(CH3)

*To 15 Fu Sensitivity

Morto Mtx:

DHFR

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dump

Enzyme

5 Fdump

T.SO

Compati

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14 T.mp

CH3?

Induction takes place

Gure Mutation

Ls Amplification

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=>

>

5 Fu

ODHFR

POSSIBLE MECHANISM OF RESISTANCE NCE : ?

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2

FUNCTION OF MAR PUMPS: Drug Effleve

USES OF MTX;

Neoplasti

I Non neop

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* Dox >

* Doc ? Choriocarcinoma *

* Ectopi

*TOsteosarcoma *.

* Graft

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• Ifoffamide

• Doxorubicin

*MULTIPLO

Cisplatin

* Leukemia (CNS-Intrathecal

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route)

Cutaneous Trell lymphoma

* Psori

srouracil

* Thymedire pre

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uses.

1.) Colorectal Cancer

Regimen = p Folive Acid

Folinic Acid

?.) Head and Neck Caucer.

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? 5 Fut as platin

Hypometaxation)

* Decetabine

Mon Demethylation

use Myelodysplasia (ONB-15)

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TII PURINE Analogues

I devrurs

Guanine

Hypoxanthing

6- Mercaptopurine

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6- Thisguamie

*ure: - Lenkerna

T

/

HGPRT

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G

?

* Sle:- Bone Marrow Suppression

Hepatotoxicity

I

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J

TI Intübitors

IRINOTECAN [Prodrug]

USE- Colorectal

Ca

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LIVER

S/E ? Cholinergic toxicity

CIT

?

Diarnhea

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+

SN-38

7

use

sle

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Acture nedaba

MICROTUBULES

?

Polymoriyation

?

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L-tubulije B-tubitur

?

9/ * CNS 4

1

CNSSY

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2 Phagocyt

PNS Axonal

MoA:-

* VINKA ALKALOIDS B tubulin

* TAXANES ? tubuhit

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* Ixabepmone Stabiliges M.T.

I Castoroil

SK-M/C) Hypersensitiv

Ti) Peripheral Neuropat

* DOCETAXEL

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Can Cause 20 netention

? Ixabepmone:

use: Breast Ca

? Intravenous ro

?

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In systemic Cor

woto Aspartate

Lymphocytes Othercells

use: * LEUKEMIA

* LYMPHOMA

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S/effects: * & protein Gynthesis

* ? Insulin Syvethesis Hyp

* Hyperlipidemia PANCR

SA.CF

* CF Jed

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* Hype ?

Hypersensitivity

He

? The

best dou

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Multiple myeloma (Best

TOS: / BORTEZOMIB+ LENALIDOMIDE &

5/6 :: * Thrombocytopenia

I Carrier of

(4) (IMMUNO TOXINS

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? Dearmcerin Difitox

?

15-2 1 Dephtheria toxit

? It2R.

=>

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Use:-

(Dacells.

* DASATINIB

* BOSUTINIB.

* PONATINIB.

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*CABOZANTINIB: Doc for medullary thyr

* REGORAFINIB :- • GIST.

? E.G.F.R (Her-1) 2T.KO

17.K

RO

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EGFR

(MAb)

CETUXIN

PANITU

Chemicals T.k

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*SORAFINIB DOC? H.C.C.

* PAZOPANIB ? Soft tissue Sarcoma TRAMACIRL

* SUNITINIB ?.GIST

SIDE EFFECTS: • panicreate Cancer.

use

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I) Delayed Wound healing Stopped

? HGFR T-KO:

* CRIZOTINIB use: NS Ca hung

? JGK T-KO

to Rcaxelotinib use. Myelofimosin

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? M.S

?TTP

?AIHA

M/C Side effect

INFUSION REACTIONS

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*

Medullary (F.

Medullary CA

resistant to

acture

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FL-17

Anti FL-17 Ab

* Secucinumab PSORIASIS

Anti GD2 ganghoside Ab

+

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* Dinutuximab / Highrise Neuroblo

* CHOLINERGICS.

a) Direct

b.) Indvrict

BBB

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Dont Gross

BBB

TOPICAL

(Ocular)

CNSals S/E CENTRAL

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No

we. Peripheral Nutral

S/E

* PILOCARPINE

uses. I) Glaucoma

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(Closed angle)

II) Xerostomia

?.) In Acute attack of glaucoma & closed augh

Doc:- I/v Acetazolamide

1

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Normal Iop

?

Topical PILOCARPINE

1) chronic glaucoma (Openangle)

* Pa Analogues

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(Reversible!

Tr

Tertiary armines

Quarter

* Physostigmine

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uses Glaucoma

(Closed

L? Doc Antihistaminie

(Mie)

Poisoning

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• Belladona

Poisoning (Banana)

* Donepezil, 2

* Revastigmine

& Gallantamine

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DOL

(ALZHEIMER'S)

to Taurine (Hepato tour)

ond NMDAG

Amermantie

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Oryano

Phosphate

* Pralidoxime 2

* Obidoxime

hat we ates * Drcutyl monoxing

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Carbamat

"ACH

breakdown

? {op Coube

ACHE

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Scarbamates.

Doc for

Alims

ATROPING

F (B2 Agonit)

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* Ipratropium

* Tiotropium Doc [Long

* Oxitropium

* Cemexlidium

5/6 :- Uurive Retention (worsen 1.

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HEART :-

? HR

? Conduction

* Force of Contraction

used in Rx of Brady arrhythm

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STRESS INCONTINENCE.

"Drugs:-

Doc

L' Agonist :- INE ? SNRT (DULOXETINE

?) 33. urge incontricufe

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AIPG 16.

Drugs.. MERABEGRON

B3Agonid:

TROSPIUM

Darifonacur

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? Golefenacin

24

No

CNS Side

effects

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M

M2

M3

.

?

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• Fo

0

• To

* Rate initting Enzymes Ne is

a

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RECEPTORS GPERS/SB

2. receptors!

(Gi)

NE

NE

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? a? (Ga)

0

BLOOD VO

TB1 (?MLCK)

HEART

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? HR

?0.0

? Conduction

2) KIDNEY,

7/32

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?Contraction

HALCP

?EMLCK

?

kt channel

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BLOOD VESSELS

? Ramin 1.BP. FIRS

Utorees

C/I in Im route

a.) (nuscle Necrosis

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*.DResidopa (2014)

? prodreng of NE

? use: f Neurogane hypotension

* ISOPRENALINE:


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