Download MBBS WBUHS Microbiology Paper I March April 2024 2nd Year Question Paper

The West Bengal University of Health Sciences

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MBBS 2nd Professional Examination (New Regulation) March - April 2024

Subject: Microbiology Full Marks: 100

Paper: I Time: 3 hours

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Attempt all questions. The figures in the margin indicate full marks.

1. a) A 8 year old child presented to pediatric OPD with swollen, red and tender joint which migrate from one joint to another. Past H/O sore throat 3 weeks back was reported. On auscultation, murmur was heard over the mitral valve area. 2+5+3+5
   1. What is the clinical diagnosis and etiological agent?
   2. Enlist different toxins and enzymes produced by this organism.
   3. Describe the pathogenesis disease.

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   4. Mention serological tests to be done for this etiological agent with significant titre of these tests.
   b) A diabetic 60 year old lady was admitted to an ICU following a road traffic accident where she was placed on a ventilator. An initial chest x-ray was reported as normal. Five days after admission the patient's condition deteriorated. She developed an elevated temperature, neutrophilia and signs of bilateral basal consolidation in the chest. 1+2+2+6+4
   1. What is the clinical diagnosis?
   2. Name the likely aetiological agents.
   3. Describe the factors leading to the development of pneumonia in this condition.
   4. Discuss in brief the laboratory diagnosis of this case.

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   5. Enumerate the types of hospital acquired infections.
2. a) Name the various methods of horizontal gene transfer. Discuss in detail about mechanism of conjugation. 3+7
   b) What are the different components of innate immunity? How does it differ from adaptive immunity? Describe in brief the components of adaptive immunity. 4+2+4
   c) Write down the laboratory diagnosis of intestinal amoebiasis. 10

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3. Write short notes on: 5+5
   1. Bacterial capsule.
   2. Demonstration of respect for patient's sample.
4. Explain the following statements: 5 x 4
   1. Motility helps in the laboratory diagnosis of syphilis.
   2. Antibiotic stewardship is a priority for proper patient management.

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   3. Mutation may be induced by various chemical agents.
   4. Infusion of a sterile solution containing endotoxin may causes serious illness.
   5. Culture is very important for the species identification in a case of dermatophytosis.
5. FirstRanker.com Choose the correct option for each of the following: 10 x 1
   1. Lysogenic conversion has got role in pathogenicity of:
      1. Vibrio Cholerae.

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      2. ETEC.
      3. Mycobacterium tuberculosis.
      4. Enterococcus faecalis.
   2. L-form and spheroplasts are sensitive to:
      1. Bacitracin.

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      2. Vancomycin.
      3. Cefoperazone.
      4. Tetracyclin.
   3. All the following automated systems can perform antimicrobial susceptibility testing, except:
      1. VITEK 2.

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      2. MALDI-TOF.
      3. Phoenix.
      4. Micro scan Walkaway.
   4. How is Crimean congo haemorrhagic fever virus transmitted to humans?
      1. Body fluids of infected rodents.

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      2. Droplet nuclei.
      3. Consumption of contaminated water.
      4. Bite of infected ticks.
   5. Which of the following paramyxoviruses has a surface glycoprotein lacking hemagglutinin activity?
      1. Mumps.

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      2. Measles.
      3. Respiratory syncytial virus.
      4. Parainfluenza virus type 1.
   6. Following bacteria, usually does not cause infective endocarditis, beyond 6 month of age:
      1. Enterococcus faecium

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      2. Streptococcus bovis.
      3. Staphylococcus aureus.
      4. Listeria monocytogenes.
   7. Heat-labile toxin of ETEC acts by which of the following mechanisms?
      1. Attachment and effacement.

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      2. Activation of adenylyl cyclase.
      3. Aggregative adherence.
      4. Ribosomal dysfunction.
   8. Sometimes, the plasmid may integrate with chromosomal DNA of bacteria and such plasmids are called as:
      1. Episomes.

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      2. Vectors.
      3. Transfer factors.
      4. Cosmids.
   9. A mother states that she has observed her 3 year old son scratching his anal area frequently. The most likely causative agent for this condition is
      1. T. vaginalis.

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      2. E. vermicularis.
      3. A. lumbricoides.
      4. N. americanus.
   10. Spirochete shows all types of motility except:
       1. Corkscrew.

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       2. Gliding.
       3. Flexion-Extension.
       4. Translatory.

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