Download MBBS WBUHS Pathology Paper II March April 2024 2nd Year Question Paper

Time: 3 hours

Attempt all questions. The figures in the margin indicate full marks.

1. a) A 59 year old male presented with weight loss, painless hematuria, flank pain and a large mass in lower abdomen.
   1. What is your provisional diagnosis?
   2. How will you proceed to investigate the patient in the laboratory?
   3. Describe the gross and microscopic features of the lesion.

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   3+6+6

   
   b) A 45 year old male was brought to the hospital with complain of uneasiness and squeezing type of pain in chest radiating to left arm. His ECG showed ST elevation and T inversion in lead V3, V4.
   1. What is the provisional diagnosis?
   2. Discuss the pathogenesis of this condition.
   3. What laboratory investigations are to be done to confirm the diagnosis?

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   4. Mention the complications of this condition.

   2+6+4+3

2. Answer the following:
   1. Classify Hodgkin's disease. Describe the microscopic feature of the mixed cellularity type. Describe the features of diagnostic cell present in Hodgkin's disease.

      3+3+4

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   2. Briefly discuss the pathogenesis of cirrhosis of liver.

      10

   3. Describe the pathogenesis of acute (pyogenic) osteomyelitis.

      10

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3. Write short notes on:
   1. Retinoblastoma.
   2. Prognostic factors for invasive breast carcinoma.

   2x5

4. Explain the following statements:
   1. Bronchiectasis results from a defect in airway clearance.

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   2. The most important prognostic factor in colorectal adenocarcinoma are depth of invasion and the presence of lymph node metastases.
   3. Pigment gallstones are seen in chronic haemolytic anaemia.
   4. FNAC cannot replace histological study.
   5. Dysgerminoma is the ovarian counterpart of testicular seminoma.

   5x4

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5. Choose the correct option for each of the following:
   1. Following are associated with EB virus infection except:
      1. Infectious mononucleosis.
      2. Nasopharyngeal carcinoma.
      3. Epidermodysplasia verruciformis.
      4. Oral hairy leucoplakia.

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   2. Most common gene involved in familial male breast cancer:
      1. BRCA-1.
      2. BRCA-2.
      3. P53.
      4. INK-2.

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   3. Bronchial asthma is predominantly mediated by:
      1. TH2 lymphocytes and IgE.
      2. TH1 lymphocytes and IgE.
      3. Regulator T lymphocytes and IgE.
      4. Cytotoxic T lymphocytes and IgE.

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   4. MaCallum patch is seen in:
      1. Myocardial infarction.
      2. Atherosclerosis.
      3. Rheumatic heart disease.
      4. SLE.

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   5. All are features of alcoholic steatohepatitis except:
      1. Hepatocyte swelling and necrosis.
      2. Ground glass hepatocytes.
      3. Mallory-Denk bodies.
      4. Neutrophilic infiltration.

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   6. Renal papillary necrosis is seen in:
      1. Urinary tract obstruction.
      2. Sickle cell disease.
      3. Diabetes mellitus.
      4. All of the above.

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   7. Codman triangle is a radiological finding in:
      1. Chondrosarcoma.
      2. Giant cell tumor.
      3. Ewing sarcoma.
      4. Osteosarcoma.

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   8. Charcot Leyden crystals and Cruschmann's spirals are seen in:
      1. Bronchial asthma.
      2. Chronic bronchitis.
      3. Bronchiectasis.
      4. Emphysema.

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   9. All of the following are germ cell tumours except:
      1. Mesonephroid tumors
      2. Dysgerminoma.
      3. Teratoma.
      4. Endodermal sinus tumour.

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   10. All are sex cord stromal tumor except:
       1. Granulosa cell tumor.
       2. Sertoil leydig cell tumor.
       3. Embryonal carcinoma.
       4. Fibroma thecoma of ovary.

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   10×1