Download MBBS WBUHS Pharmacology Paper II July August 2024 2nd Year Question Paper

Time: 3hours

Attempt all questions. The figures in the margin indicate full marks.

1. a) A 34 year old woman was on combined OCP. She was diagnosed as a case of pulmonary TB and was prescribed HRZE daily for 2 months followed by HR thrice weekly for 4 months. In the 3rd month of treatment she failed to have withdrawal bleeding during the gap period of contraceptive cycle. Her pregnancy test was positive one week later.
   1. What is the reason for contraceptive failure?
   2. Write down the mechanism of action of OCP.
   3. What are the serious complications of OCP use?

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   4. Add a note on other health benefits of OCP use other than prevention of unwanted pregnancy.
   2+5+5+3
   b) A 34 year old man is being prepared for an abdominal surgery with pre anesthetic medications.
   1. What is pre anesthetic medication?
   2. Enumerate the drugs to be used as pre anesthetic medications with individual specific reasons of their requirement.
   3. What are the disadvantages of pre anesthetic medications?

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   2+(5+5)+3
2. a) Classify Gluco-corticoids as per their duration of action. Write down the uses and adverse effects of corticosteroids. 3+3+4
   b) A patient came to medicine OPD with features of gout.
   1. Enumerate the drugs used in acute gout.
   2. Allopurinol is used for what purpose and how does it help in gout?
   3. Why should allopurinol not be used with 6-mercaptopurine?

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   3+4+3
   c) What is the treatment regimen for chloroquine resistant falciparum malaria? Explain the role of primaquine as an antimalarial agent. Mention two extra malarial uses of chloroquine. 4+4+2
3. Write short notes on following:
   1. Sodium glucose Co-transporter-2 inhibitors.
   2. Anti Pseudomonal antibiotics.
   5 x 4

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4. Explain the following statements:
   1. Imipenem is administered with cilastin.
   2. Bupivacaine injected epidurally has become very popular in obstetrics.
   3. Clopidogrel should not be co-administered with omeprazole.
   4. Non selective MAO inhibitors should not be combined with pethidine.
   5. Morphine is contraindicated in head injury.

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   10 x 1
5. Choose the correct option for each of the following:
   1. What is true regarding tolerance occurring in regular opium abusers?
      1. Tolerance develops to all actions of morphine.
      2. No tolerance occurs to euphoric and sedative actions of morphine.
      3. No tolerance occurs to constipating and miotic actions of morphine.
      4. Lethal dose of morphine is not significantly increased.

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   2. The 'neuroleptic syndrome' produced by chlorpromazine like drugs is characterized by the following except:
      1. Emotional quietening
      2. Paucity of movements
      3. Ataxia
      4. Indifference to external cues

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   3. The success of oral rehydration therapy of diarrhea depends upon the following process in the intestinal mucosa:
      1. Sodium pump mediated sodium absorption
      2. Glucose coupled sodium absorption
      3. Bicarbonate coupled sodium absorption
      4. Passive sodium diffusion secondary to nutrient absorption

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   4. Shortest acting proton pump inhibitor is:
      1. Omeprazole
      2. Pantoprazole
      3. Lansoprazole
      4. Rabeprazole

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   5. Ezetimibe acts by:
      1. Enhanced excretion of bile acids
      2. Decreased absorption of cholesterol
      3. Inhibiting HMG-CoA reductase
      4. Inhibiting intracellular lipase

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   6. Drug causing deafness is:
      1. Thiazide
      2. Spironolactone
      3. Ethacrynic acid
      4. Triamterene

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   7. Antiemetic known as hurrying agent is:
      1. Metoclopramide
      2. Ondansetron
      3. Aluminium hydroxide gel
      4. Magnesium hydroxide

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   8. Tetracyclines:
      1. Have three cyclic rings in its structure
      2. Inhibits cell wall synthesis
      3. Causes grey baby syndrome
      4. Can precipitate fatal acute hepatic necrosis in pregnant woman

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   9. Which of the following drugs does not affect GABAa gated chloride channel?
      1. Alcohol
      2. Picrotoxin
      3. Muscimol
      4. Buspirone

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   10. Least sedative antihistaminic drug is:
       1. Fexofenadine
       2. Cetrizine
       3. Chlorpheniramine
       4. Diphenhydramine

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   2 x 5