QP CODE : 1025
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase – I (CBME) Degree Examination - 09-Feb-2024
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Time: Three Hours
Max. Marks: 100 Marks
BIOCHEMISTRY – PAPER II (RS-4)
Q.P. CODE: 1025
(QP contains three pages)
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Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks
- A fair 5 year old child was brought to the hospital by his parents, who complained of delayed milestones in the child. Investigations revealed a high phenylalanine content in the blood and a diagnosis of phenylketonuria was made.
- Name the enzyme defect in the above disorder.
- Explain the pathway for catabolism of phenylalanine.
- Name the compound responsible for the mousy odour in the above condition.
- List the biochemical investigations in phenylketonuria
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- Explain the process of recombinant DNA technology and list four applications in the field of medicine.
SHORT ESSAYS 8 x 5 = 40 Marks
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- A 40 year old female with history of gall stones presented with acute pain abdomen, yellowish discoloration of sclera and passing clay coloured stools. Following investigations, a diagnosis of obstructive jaundice was made.
- Describe van Den Berg test and its findings in this condition.
- Name the enzyme that is elevated in this condition.
- Explain the biochemical reason for clay coloured stools in this case.
- A 50 year old female presented with hoarseness of voice, dryness of skin and excess weight gain. The case was suspected to be hypothyroidism.
- List the tests for assessment of thyroid function.
- Write laboratory findings in a case of hypothyroidism.
- Differentiate between primary and secondary hypothyroidism.
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- Define proto-oncogene and oncogene. Explain the activation of oncogene.
- Compare and contrast between replication in prokaryotes and eukaryotes.
- Enumerate kidney function tests. Explain tubular function test.
- Describe DNA repair mechanism with suitable examples.
- What is gout? Write the causes and clinical features of gout.
- Enumerate the functional classification of proteins with examples.
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Page 1 of 3
SHORT ANSWERS 10 x 3 = 30 Marks
- Draw and label the cell cycle.
- What are histones? Enumerate their functions.
- Draw a neat labelled diagram of immunoglobulin.
- What are restriction endonucleases? Mention their importance.
- Give biological reference interval of serum urea, serum albumin and serum creatinine.
- Enumerate post-transcriptional modifications and write their significance.
- Mention any three antioxidants and state their mechanism of action.
- Write the structure and function of t-RNA
- Give three examples for detoxification by conjugation mechanism.
- Name three pre-analytical variables that affect the biochemical laboratory results.
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Multiple Choice Questions 10 x 1 = 10 Marks
- Which of the following is an essential amino acid?
- Glycine
- Phenyl alanine
- Aspartic acid
- Serine
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- Hypoalbuminemia is seen in all the following conditions EXCEPT
- Cirrhosis of liver
- Nephrotic syndrome
- Kwashiorkor
- Dehydration
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- Which of the following is a secretory immunoglobulin?
- IgG
- IgA
- IgM
- IgD
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- Deficiency enzyme causing
- Tyrosinase
- Fumarylacetoacetate hydrolase
- Homogentisate oxidase
- Dopa decarboxylase
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- Bile salts and bile pigments are excreted in urine in
- Incompatible blood transfusion
- Gilbert's syndrome
- Carcinoma of head of pancreas
- Crigler-Najjar syndrome
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- Which of the following conditions is not associated with hyperuricemia?
- Gout
- Leukemia
- Psoriasis
- Xanthinuria
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- CA 125 is a tumor marker for
- Ovarian cancer
- Hepatoma
- Carcinoma breast
- Pheochromocytoma
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- Which of the following is an example of enzyme which scavenges free radicals?
- Hexokinase
- Aconitase
- Fumarase
- Catalase
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- α-1 antitrypsin deficiency is associated with
- Wilson's disease
- Cirrhosis of liver
- Emphysema
- Multiple myeloma
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- Clearance values of all of the following compounds are used to test glomerular function of kidney EXCEPT
- Glucose
- Creatinine
- Inulin
- Urea
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Page 3 of 3
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