Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase - II (CBME) Degree Examination - 02-Mar-2022
Time: Three Hours Max. Marks: 100 Marks
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PHARMACOLOGY - PAPER I (RS-4)Q.P. CODE: 1028
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
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LONG ESSAYS 2 x 10 = 20 Marks
- Define Bioavailability? Discuss the factors affecting Bioavailability
- A 42 years old farmer was brought to casualty with symptoms of irritation of eyes, lacrimation, excessive salivation, blurring of vision, breathlessness, involuntary defecation and urination. Based on these symptoms physician made a diagnosis of acute organophosphorous compound poisoning.
- Discuss the management of Organophosphorous Poisoning
- Enumerate the uses of reversible anticholinesterases
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SHORT ESSAYS 8 x 5 = 40 Marks
- Drug Synergism with examples
- Advantages and Four uses of Cardioselective beta blockers
- Mechanism of action, adverse effects and uses of Phenytoin
- Pharmacological actions and uses of Aspirin
- Mention two groups of drugs used as bronchodilators with examples. Describe their mechanism of action.
- Mention Four atypical antipsychotics. Describe their advantages over conventional antipsychotics.
- A 70 year old patient suffering from Lung carcinoma with metastases is requesting for analgesics. The doctor decided to prescribe Morphine for pain relief.
- Explain the mechanism of analgesic action of morphine in this patient.
- Mention the contraindications for Morphine.
- A 55 year old patient complained of dyspepsia and epigastric pain since a month. He underwent endoscopy which confirmed H.Pylori positive peptic ulcer. The physician prescribed anti H.Pylori regimen. Write any two anti H Pylori drug regimens.
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SHORT ANSWERS 10 x 3 = 30 Marks
- Define Tachyphylaxis. Mention two drugs exhibiting it
- Advantages of Domperidone over Metoclopramide
- Mention three techniques of administering Local Anaesthetic agents with one indication for each technique
- Mention three drugs used for pre-anaesthetic medication
- Rationale of using Dantrolene in Malignant Hyperthermia
- Rationale of using Methotrexate in Rheumatoid arthritis
- Rationale of using Adrenaline in Anaphylactic shock
- Rationale of using Montelukast in Bronchial asthma
- Write three rational Fixed dose combination of drugs
- Mention three uses of d-Penicillamine
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QP CODE : 1028
Multiple Choice Questions 10 x 1 = 10 Marks
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- i) Low dose of aspirin prolongs bleeding time by selectively inhibiting synthesis of following mediator in the platelets
- Thromboxane
- 5-Hydroxytryptamine
- Platelet activating factor
- Prostacyclin
- ii) Which of the following drug causes Tolerance
- Adrenaline
- Morphine
- Dopamine
- Isoprenaline
- iii) Which of the following is a prodrug of adrenaline used topically in glaucoma
- Brimonidine
- Dipivefrine
- Dorzolamide
- Timolol
- iv) Receptor agonist exhibits
- Affinity, but no intrinsic activity
- Intrinsic activity, but no affinity
- Both affinity and intrinsic activity
- Neither affinity nor intrinsic activity
- v) The following mydriatic does not produce cycloplegia
- Phenylephrine
- Tropicamide
- Cyclopentolate
- Homatropine
- i) Bronchodilator which requires Therapeutic drug monitoring is
- Salbutamol
- Theophylline
- Formeterol
- Ipratropium Bromide
- ii) Primary mechanism of action of diazepam is
- Dopamine antagonism
- Adenosine antagonism
- GABA facilitatory action
- 5-HT antagonism
- iii) Which of the following is not useful in treating drug induced Parkinsonism
- Levodopa
- Biperiden
- Procyclidine
- Trihexyphenidyl
- iv) Local anaesthetics act by blocking neuronal
- Sodium channel
- Calcium channel
- Chloride channel
- Potassium channel
- v) Purgative used in the management of hepatic encephalopathy is
- Bisacodyl
- Liquid Paraffin
- Methylcellulose
- Lactulose
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This download link is referred from the post: RGUHS MBBS 2nd Year Last 15 Years 2010-2025 Previous Question Papers (Rajiv Gandhi University of Health Sciences)
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