Download RGUHS (Rajiv Gandhi University of Health Sciences) MBBS (Bachelor of Medicine and Bachelor of Surgery) 2nd Year (Second Year) 2022 March 1028 Pharmacology Paper I Rs 4 Previous Question Paper
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase ? II (CBME) Degree Examination - 02-Mar-2022
Time: Three Hours
Max. Marks: 100 Marks
PHARMACOLOGY ? PAPER I (RS-4)
Q.P. CODE: 1028
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS
2 x 10 = 20 Marks
1.
Define Bioavailability? Discuss the factors affecting Bioavailability
2.
A 42 years old farmer was brought to casualty with symptoms of irritation of eyes,
lacrimation, excessive salivation, blurring of vision, breathlessness, involuntary defecation
and urination. Based on these symptoms physician made a diagnosis of acute
organophosphorous compound poisoning.
a) Discuss the management of Organophosphorous Poisoning
b) Enumerate the uses of reversible anticholinesterases
SHORT ESSAYS
8 x 5 = 40 Marks
3. 1. Drug Synergism with examples
4. 2. Advantages and Four uses of Cardioselective beta blockers
5. 3. Mechanism of action, adverse effects and uses of Phenytoin
6.
Pharmacological actions and uses of Aspirin
7.
Mention two groups of drugs used as bronchodilators with examples. Describe their
mechanism of action.
8.
Mention Four atypical antipsychotics. Describe their advantages over conventional
antipsychotics.
9.
A 70 year old patient suffering from Lung carcinoma with metastases is requesting for
analgesics. The doctor decided to prescribe Morphine for pain relief.
a) Explain the mechanism of analgesic action of morphine in this patient.
b) Mention the contraindications for Morphine.
10. A 55 year old patient complained of dyspepsia and epigastric pain since a month. He
underwent endoscopy which confirmed H.Pylori positive peptic ulcer. The physician
prescribed anti H.Pylori regimen. Write any two anti H Pylori drug regimens.
SHORT ANSWERS
10 x 3 = 30 Marks
11. Define Tachyphylaxis. Mention two drugs exhibiting it
12. Advantages of Domperidone over Metoclopramide
13. Mention three techniques of administering Local Anaesthetic agents with one indication for
each technique
14. Mention three drugs used for pre-anaesthetic medication
15. Rationale of using Dantrolene in Malignant Hyperthermia
16. Rationale of using Methotrexate in Rheumatoid arthritis
17. Rationale of using Adrenaline in Anaphylactic shock
18. Rationale of using Montelukast in Bronchial asthma
19. Write three rational Fixed dose combination of drugs
20. Mention three uses of d-Penicillamine
Page 1 of 2
QP CODE : 1028
Rajiv Gandhi University of Health Sciences, Karnataka
Multiple Choice Questions
10 x 1 = 10 Marks
21 i) Low dose of aspirin prolongs bleeding time by selectively inhibiting synthesis of following
mediator in the platelets
A. Thromboxane
B. 5-Hydroxytryptamine
C. Platelet activating factor
D. Prosta
cyclin
21 ii
) Which of the following drug causes Tolerance
A. Adrenaline
B. Morphine
C. Dopamine
D. Isopre
naline
21 ii
i) Which of the following is a prodrug of adrenaline used topically in glaucoma
A. Brimonidine
B. Dipivefrine
C. Dorzolamide
D. Ti
molol
21 iv)
Receptor agonist exhibits
A. Affinity, but no intrinsic activity
B. Intrinsic activity, but no affinity
C. Both affinity and intrinsic activity
D. Neither
affinity nor intrinsic activity
21 v)
The following mydriatic does not produce cycloplegia
A. Phenylephrine
B. Tropicamide
C. Cyclopentolate
D. Homatr
opine
22 i) Bronchodilator which requires Therapeutic drug monitoring is
A. Salbutamol
B. Theophylline
C. Formeterol
D. Ipra
tropium Bromide
22
ii) Primary mechanism of action of diazepam is
A. Dopamine antagonism
B. Adenosine antagonism
C. GABA facilitatory action
D. 5-HT
antagonism
22 iii) Which of the following is not useful in treating drug induced Parkinsonism
A. Levodopa
B. Biperiden
C. Procyclidine
D. Trihexy
phenidyl
22 iv)
Local anaesthetics act by blocking neuronal
A. Sodium channel
B. Calcium channel
C. Chloride channel
D. Potassium
channel
22 v)
Purgative used in the management of hepatic encephalopathy is
A. Bisacodyl
B. Liquid Paraffin
C. Methylcellulose
D. La
ctulose
******
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This post was last modified on 02 December 2024