QP CODE: 1028
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase - II (CBME) Degree Examination - 03-Jun-2024
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Time: Three Hours Max. Marks: 100 Marks
PHARMACOLOGY – PAPER I (RS-4)
Q.P. CODE: 1028
(QP contains two pages)
Your answers should be specific to the questions asked
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Draw neat, labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks
- Define Drug antagonism. Discuss the different types of drug antagonism with suitable examples.
- A 75 year old patient presents with defective gait and posture, mask like face and Sialorrhoea. On examination, he had rigidity, tremors and hypokinesia. He was diagnosed to be suffering from Parkinsonism.
- Classify Antiparkinsonian drugs with suitable examples
- Discuss the Pharmacological actions and adverse effects of Levodopa
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SHORT ESSAYS 8 x 5 = 40 Marks
- Therapeutic uses and adverse effects of Alpha Blockers
- Define Bioavailability of a drug. Explain four drug related factors affecting bioavailability
- Cardiovascular actions of Adrenaline
- Compare and contrast Physostigmine and Neostigmine
- Pharmacological actions and adverse effects of Aspirin
- Inhalational glucocorticoids in Bronchial asthma
- A 38 year old patient after surgery for fracture femur is given Metoclopramide for antiemetic action.
- Explain the rationale of using metoclopramide in this patient.
- Write its adverse effects and uses.
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- A 30 year old patient is brought to hospital with delusional beliefs, auditory hallucinations, restlessness, disturbed sleep and inappropriate behaviour. She was diagnosed to be suffering from schizophrenia and prescribed Olanzapine.
- Explain the rationale of using Olanzapine in this patient.
- Write its advantages over conventional antipsychotics.
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SHORT ANSWERS 10 x 3 = 30 Marks
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- What is therapeutic drug monitoring (TDM)? Write two drugs requiring TDM
- Rationale of using Atropine in Organophosphorous compound poisoning
- Rationale of using Morphine in acute pulmonary oedema
- Write two adverse effects of Phenytoin. Why is phenytoin contraindicated in pregnancy?
- Write three nondepolarising skeletal muscle relaxants
- Name two anti-motility drugs. Why are they contraindicated in Shigella dysentery?
- Write Two advantages and Two disadvantages of selective Cox 2 inhibitors
- Name three antitussives
- Explain the concept of Essential medicines (drugs)
- Write three uses of Calcium Disodium edetate
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Multiple Choice Questions 10 x 1 = 10 Marks
- An 18 year old female patient is brought to hospital in an unconscious state following accidental drug overdose. Which of the following route is desirable for administering the antidote for this patient?
- Oral
- Transdermal
- Intravenous
- Subcutaneous
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- Which of the following is a prodrug?
- Hydralazine
- Levodopa
- Paracetamol
- Aspirin
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- Apraclonidine is a congener of clonidine used for
- Pain relief
- Reducing Blood pressure
- Reducing intraocular tension
- Reducing blood glucose
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- Atropine produces all the following actions EXCEPT
- Tachycardia
- Dryness of mouth
- Mydriasis
- Urinary incontinence
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- A 8 year old boy was brought by the mother with momentary loss of consciousness. EEG shows spike and wave pattern. Pediatrician made a diagnosis of absence seizures. Which of the following drug is useful for absence seizures?
- Phenobarbitone
- Sodium Valproate
- Phenytoin
- Carbamazepine
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- Which of the following antipsychotic produces extrapyramidal side effects?
- Chlorpromazine
- Olanzapine
- Quetiapine
- Aripiprazole
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- Which antihistaminic drug produces less central nervous system depressant activity?
- Diphenhydramine
- Pheniramine
- Promethazine
- Cetrizine
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- Which of the following drug cannot be administered by inhalational route in asthma
- Montelukast
- Ipratropium bromide
- Budesonide
- Salbutamol
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- An anti-emetic can be used in a conscious patient suffering from poisoning due to all the following EXCEPT
- Iron
- Diazepam
- Kerosene
- Paracetamol
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- Essential drugs are
- Life saving drugs
- Inert drugs
- Drugs that meet the priority health care needs of the population
- Drugs that have no therapeutic use
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