SS/MBBS/BIO-I/7-16
First Professional MBBS Examination
2016
(July)
BIOCHEMISTRY
Full Marks: 50
Time: 2 hours
The figures in the margin indicate
full marks for the questions
Answer all questions
FIRST HALF
1. Discuss the organization of protein structure. Give an account of the
2. Write short notes on any three of the following : ( 4 x 3 = 12)
(a) Fluid mosaic model of membrane structure
(b) Structure of tRNA
(c) Applications of radioisotopes in biochemistry
3. An African boy (12 years) studying in an Indian school was admitted in a
hospital with complaints of fever and severe pain in arms and legs. On
examination, he was found to have hepatosplenomegaly. Lab findings are Hb--
7 g/dl (Ref. 14-16 g/dl) and haematocrit--20% (Ref. 40%-50%). Haemoglobin
haemoglobin (HbA) and microscopic examination of blood smear shows a
crescent (sickle)-shaped erythrocytes.
(a) Give a probable diagnosis. 1
(b) What is the molecular basis of the disease? 2
SECOND HALF
4. What are coenzymes? Write an account of the importance of serum
enzymes in the diagnosis of disease. 2+6=8
(a) Free radicals
(b) Biological value of proteins
(c) Haemoglobinopathies with special reference to sickle cell anaemia
(d) Major histocompatibility complex (MHC)
admitted in a hospital with a history of behavioural disturbance and epileptic
form of seizures. Clinical examination revealed that the boy had an enlarged
liver. His cornea showed the presence of Kayser-Fleischer ring. The laboratory
findings were as follows:
(Ref. 100-200 g/dl)
Serum ceruloplasmin--5 mg/dl
(Ref. 25-50 mg/dl)
Urinary copper--200 g/dl (Ref. <25 g/dl)
(a) Give the probable diagnosis. 1
(b) What are the probable causes of the disease? 2
(c) What is the drug of choice and what is its mechanism of action? 2
*******
First Professional MBBS Examination
2016
(July)
BIOCHEMISTRY
--- Content provided by FirstRanker.com ---
Paper-IFull Marks: 50
Time: 2 hours
The figures in the margin indicate
full marks for the questions
--- Content provided by FirstRanker.com ---
Write the answers to the two Halves in separate booksAnswer all questions
FIRST HALF
1. Discuss the organization of protein structure. Give an account of the
--- Content provided by FirstRanker.com ---
determination of primary structure of proteins. ( 6+2=8)2. Write short notes on any three of the following : ( 4 x 3 = 12)
(a) Fluid mosaic model of membrane structure
(b) Structure of tRNA
(c) Applications of radioisotopes in biochemistry
--- Content provided by FirstRanker.com ---
(d) Nucleosome3. An African boy (12 years) studying in an Indian school was admitted in a
hospital with complaints of fever and severe pain in arms and legs. On
examination, he was found to have hepatosplenomegaly. Lab findings are Hb--
7 g/dl (Ref. 14-16 g/dl) and haematocrit--20% (Ref. 40%-50%). Haemoglobin
--- Content provided by FirstRanker.com ---
electrophoresis shows a distinct HbS band with slower movement than adulthaemoglobin (HbA) and microscopic examination of blood smear shows a
crescent (sickle)-shaped erythrocytes.
(a) Give a probable diagnosis. 1
(b) What is the molecular basis of the disease? 2
--- Content provided by FirstRanker.com ---
(c) What are the abnormalities associated with HbS? 2SECOND HALF
4. What are coenzymes? Write an account of the importance of serum
enzymes in the diagnosis of disease. 2+6=8
--- Content provided by FirstRanker.com ---
5. Write short notes on any three of the following: 4?3=12(a) Free radicals
(b) Biological value of proteins
(c) Haemoglobinopathies with special reference to sickle cell anaemia
(d) Major histocompatibility complex (MHC)
--- Content provided by FirstRanker.com ---
6. A school boy, aged 12 years, complained of abdominal pain and wasadmitted in a hospital with a history of behavioural disturbance and epileptic
form of seizures. Clinical examination revealed that the boy had an enlarged
liver. His cornea showed the presence of Kayser-Fleischer ring. The laboratory
findings were as follows:
--- Content provided by FirstRanker.com ---
Serum copper--40 g/dl(Ref. 100-200 g/dl)
Serum ceruloplasmin--5 mg/dl
(Ref. 25-50 mg/dl)
Urinary copper--200 g/dl (Ref. <25 g/dl)
--- Content provided by FirstRanker.com ---
(a) Give the probable diagnosis. 1
(b) What are the probable causes of the disease? 2
(c) What is the drug of choice and what is its mechanism of action? 2
*******
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SM16--1000/35 SS/MBBS/BIO-1/7-16