First Professional MBBS Examination
2019
(June)
BIOCHEMISTRY
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Paper-IFull Marks: 50
Time: 2 hours
The figures in the margin indicate
full marks for the questions
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Write the answers to the two Halves in separate booksAnswer all questions
FIRST HALF
1. What are the forces that stabilize primary, secondary and tertiary structures
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of proteins? Explain the structural organization of hemoglobin molecule, andthe effect of alteration in amino acid sequence. [ 2 + 3 + 3 = 8]
2. Write short notes on any three of the following : 4?3=12
(a) Cell membrane active transport mechanism
(b) Transamination reaction and its metabolic importance
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(c) Biological role of vitamin B12(d) Carnitine
3. Explain in short : 2?2=5
(a) Deficiency of lipotropic factors may result in fatty liver
(b) Newborn infants are at high risk of vitamin K deficiency
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SECOND HALF4. Describe in brief human body distribution and biological functions of
calcium. Give a note on calcium homeostasis. 4+4=8
5. Write short notes on any three of the following : 4?3=12
(a) Free radicals in human diseases
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(b) Plasma bicarbonate buffer(c) Competitive enzyme inhibition
(d) Diet as risk factors of atherosclerosis
6. Explain in short : 2?2=5
(a) Presence of bile salts and bile pigments in urine indicates obstructive
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jaundice(b) Severe deficiency of copper leads to hypochromic and microcytic anemia
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SM9--1120/23 SS/MBBS/BIO-1/6-19
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