KNRUHS MBBS Final Year 2013-2025 Last 10 Years Question Papers || 4th Year
First Professional MBBS Examination 2016 (July)
BIOCHEMISTRY
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Paper-II
Full Marks: 50
Time: 2 hours
The figures in the margin indicate full marks for the questions
Write the answers to the two Halves in separate books
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Answer all questions
FIRST HALF
- What are the biomedical importances of hexose-monophosphate shunt? Describe the different phases of this pathway with special reference to deficiency of its rate limiting enzyme. (2 + 6 = 8)
- Write short notes on any three of the following: 4x3=12
- Chemiosmotic hypothesis of oxidative phosphorylation
- Utilization of ketone bodies
- Alkaptonuria
- Mechanism of action of steroid hormones
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- A 40-year-old man came to surgical OPD with pain abdomen and yellowish discolouration of skin and sclera. He was also complaining of itching of whole body and passing clay-coloured stool.
- What is the probable diagnosis? 1
- What are the tests that can be done to arrive at a provisional diagnosis? 2
- What are the biochemical bases for itching and clay-coloured stool? 2
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SECOND HALF
- Write a note on transcription along with post-transcriptional processing. 4+4=8
- Write short notes on any three of the following : 4x3=12
- Principle of colorimeter and its application
- Replication fork
- Oncogenes
- Cytochrome Paso
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- Justify the following statements : 1x5=5
- Transcription error is more marked than replication error.
- Regular blood transfusion is of utmost importance in the management of B-thalassemia major.
- Mitochondrial DNA is more frequently affected by mutations than nuclear DNA.
- Methotrexate is an anticancer drug.
- Iron deficiency can lead to retarded growth.
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