SS/MBBS-I/1st1A/PHY/02-25
First Professional MBBS Examination
2025
(February)
PHYSIOLOGY
Time: 3 hours
The figures in the margin indicate
full marks for the questions
Write the answers to the two Halves in separate books
1. Define haemostasis. Enumerate the major events involved in haemostasis.
Describe the intrinsic and extrinsic systems of clotting mechanism. Explain the
role of Vitamin K in coagulation. What is thrombus? 1+3+6+3+2=15
2. Write short notes on: 5x8=40
b) Na+-K+-ATPase.
c) P-R interval in ECG.
d) Excitation-contraction coupling.
e) Surfactant.
g) Ventricular systole.
h) Strength-duration curve.
3. Describe the importance of empathy in doctor-patient relationship. 5
a) Megaloblastic anaemia occurs in Vitamin B12 deficiency.
b) Cyanosis does not occur in anaemic hypoxia.
5. Differentiate between: 2x3=6
a) Isotonic and isometric contraction.
c) Adult haemoglobin and foetal haemoglobin.
6. Describe briefly the structure of the respiratory membrane with suitable
diagram. Describe the forms of oxygen transport in blood. Describe the factors
affecting oxygen-haemoglobin dissociation curve with suitable diagram. Explain
7. A 65 year old woman comes to the primary care physician complaining of
rapid onset of fatigue, which worsens towards the evening. She also complains
of decreasing ability to read that is more pronounced in the evening. On
examination, drooping of the right upper eyelid was seen. Neurological
weakness. 2+3+2+3=10
a) What may be the probable diagnosis?
b) Write briefly on the pathophysiology of your diagnosis.
c) Write two more clinical features that are associated with your diagnosis.
8. Choose the correct answer: 1x5=5
i. According to Weibel's model, the conducting zone of respiratory tract is from
a) 1 to 16 generations
b) 17 to 19 generations
d) 1 to 20 generations
ii. Chromatolysis is seen in
a) demyelination
b) multiple sclerosis
d) during nerve activity
iii. Apart from the nucleus, which part of the cell contains DNA?
a) Endoplasmic reticulum
b) Golgi bodies
d) Peroxisomes
iv. After muscle contraction, calcium ions return to the sarcoplasmic reticulum
by
a) facilitated diffusion
secondary active transport
d) simple diffusion
v. The amount of air remaining in the lungs after forceful expiration is
a) residual volume
c) expiratory reserve volume
d) tidal volume
*****
SS/MBBS-I/1st IA/PHY/02-25
First Professional MBBS Examination
2025
(February)
PHYSIOLOGY
--- Content provided by FirstRanker.com ---
Full Marks: 100Time: 3 hours
The figures in the margin indicate
full marks for the questions
Write the answers to the two Halves in separate books
--- Content provided by FirstRanker.com ---
Answer all questions1. Define haemostasis. Enumerate the major events involved in haemostasis.
Describe the intrinsic and extrinsic systems of clotting mechanism. Explain the
role of Vitamin K in coagulation. What is thrombus? 1+3+6+3+2=15
2. Write short notes on: 5x8=40
--- Content provided by FirstRanker.com ---
a) Gap junction.b) Na+-K+-ATPase.
c) P-R interval in ECG.
d) Excitation-contraction coupling.
e) Surfactant.
--- Content provided by FirstRanker.com ---
f) A-V nodal delay and its significance.g) Ventricular systole.
h) Strength-duration curve.
3. Describe the importance of empathy in doctor-patient relationship. 5
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4. Give physiological basis of: 2x2=4a) Megaloblastic anaemia occurs in Vitamin B12 deficiency.
b) Cyanosis does not occur in anaemic hypoxia.
5. Differentiate between: 2x3=6
a) Isotonic and isometric contraction.
--- Content provided by FirstRanker.com ---
b) Graded potential and action potential.c) Adult haemoglobin and foetal haemoglobin.
6. Describe briefly the structure of the respiratory membrane with suitable
diagram. Describe the forms of oxygen transport in blood. Describe the factors
affecting oxygen-haemoglobin dissociation curve with suitable diagram. Explain
--- Content provided by FirstRanker.com ---
why PCV of venous blood is greater than that of arterial blood. 4+2+6+3=157. A 65 year old woman comes to the primary care physician complaining of
rapid onset of fatigue, which worsens towards the evening. She also complains
of decreasing ability to read that is more pronounced in the evening. On
examination, drooping of the right upper eyelid was seen. Neurological
--- Content provided by FirstRanker.com ---
examination showed normal sensory responses with small amount of muscleweakness. 2+3+2+3=10
a) What may be the probable diagnosis?
b) Write briefly on the pathophysiology of your diagnosis.
c) Write two more clinical features that are associated with your diagnosis.
--- Content provided by FirstRanker.com ---
d) Write briefly on the treatment you would suggest.8. Choose the correct answer: 1x5=5
i. According to Weibel's model, the conducting zone of respiratory tract is from
a) 1 to 16 generations
b) 17 to 19 generations
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c) 20 to 23 generationsd) 1 to 20 generations
ii. Chromatolysis is seen in
a) demyelination
b) multiple sclerosis
--- Content provided by FirstRanker.com ---
section of axond) during nerve activity
iii. Apart from the nucleus, which part of the cell contains DNA?
a) Endoplasmic reticulum
b) Golgi bodies
--- Content provided by FirstRanker.com ---
Mitochondriad) Peroxisomes
iv. After muscle contraction, calcium ions return to the sarcoplasmic reticulum
by
a) facilitated diffusion
--- Content provided by FirstRanker.com ---
b) primary active transportsecondary active transport
d) simple diffusion
v. The amount of air remaining in the lungs after forceful expiration is
a) residual volume
--- Content provided by FirstRanker.com ---
b) inspiratory reserve volumec) expiratory reserve volume
d) tidal volume
*****
SS/MBBS-I/1st IA/PHY/02-25
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