SS/MBBS-I/BIO-CHM-I/11-23
First Professional MBBS Examination
2023
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(November)BIOCHEMISTRY
Paper-I
Full Marks: 100
Time: 3 hours
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The figures in the margin indicatefull marks for the questions
Write the answers to the two Halves in separate books
Answer all questions
1. What is normal fasting-plasma glucose level? How is it regulated? What is
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impaired glucose tolerance? [2 + 8 + 5 = 15]2. Name the dietary lipids. Explain the role of bile salts in the digestion and
absorption of fats. Mention the changes observed in obstructive jaundice. [2 +
8 + 5 = 15]
3. A 42-year-old male
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presented with severe pain, redness and swelling of thebig toe in the night after a bout of alcohol consumption. He felt severe pain in
his big toe when he woke up. No history of trauma or pain in other toes was
there. Serum-uric acid was [9.7 mg/dL]
(a)What is your likely diagnosis?
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(b) What is the biochemical basis of the condition?(c) What is the treatment of the given condition and mechanism of action of
the drug prescribe? 2+4+4=10
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4. Choose the correct option : 1x10=10
(i) HbA differs from HoF in that
(a) HbA has only alpha chains
(b) HbF cannot bind to 2, 3-BPG
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(c) HbF can bind only 2 molecules of oxygen(d) HDA is alkali resistant.
(ii) Seliwanoff's test is done for
(a) glucose
(b) fructose
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(c) galactose(d) lactose
(iii) ATP synthase is a marker enzyme present in
(a) cytoplasm
(b) mitochondria
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(c) Golgi complex(d) lysosome
(iv) Denatured proteins
(a) are soluble
(b) are difficult to digest
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(c) are biologically inactive(d) Peptide bonds are broken
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(v) Which of the following cellular organelles can cause autodigestion?(a) Golgi bodies
(b) Lysosomes
(c) Microsomes
(d) Peroxisomes
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(vi) All are examples of phospholipids, except(a) lecithin
(b) ceramide
(c) sphingomyelin
(d) triacylglycerol.
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(vii) The semi-essential amino acid is(a) alanine
(b) arginine
(c) cysteine
(d) glycine
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(viii) Different polypeptide chains are held together by(a) peptide bond
(b) disulfide bond
(c) glycoside bond
(d) ester bond
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(ix) Fluidity of membrane depends on(a) nature of fatty acids
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(b) concentration of proteins(c) membrane pumps
(d) glycosylation of proteins
(x) Normal plasma cholesterol levels
(a) 40-60 mg/100 ml
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(b) 70-100 mg/100 ml(c) 120-150 mg/100 ml
(d) 150-200 mg/100 ml
5. Write short notes on the following : 5x7=35
(a) High anion gap acidosis
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(b) Sources and fate of acetyl-CoA(c) Essential fatty acids
(d) Biological action of glutathione
(e) Rental buffer systems
(f) Glucose 6 phosphate dehydrogenase deficiency
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(g) Levels of protein organization6. Justify the followin
g statements : 2x5=10
(a) Conversion of pyruvate to lactate is an example of fermentation.
(b) Preduodenal lipases are important for newborn infants.
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(c) There is cataract in galactosemia.(d) There is increased bleeding tendency in vitamin C deficiency.
(e) Key enzyme in cholesterol synthesis is used as a therapeutic target.
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7. What is the doctor-patient relationship in medical ethics? 5
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