Total No. of Printed Pages - 2
SS/MBBS-I/1st IA/ BIO /08-24
2024
(August)
BIOCHEMISTRY
Full Marks: 90
Time: 2 hours 50 minutes
The figures in the margin indicate
full marks for the questions
1. Describe the levels of organization of protein structure. Enumerate the
functions of protein in the human body. Write briefly about the structure-
function relationship of protein with special reference to haemoglobin.
[6 + 5 + 4 = 15]
note on disorders associated with it. What is the significance of -oxidation?
[(6 + 3) + 3 + 3 = 15]
3. A 5-year-old boy was admitted to the paediatric ICU with complaints of
weakness, fatigability, generalized body swelling, and decreased urinary
the whole body. His blood sample was sent for investigations. The laboratory
report revealed--Total proteins: 5 g/dl, albumin: 2 g/dl, globulin: 3 g/dl, total
cholesterol: 400 mg/dl, LDL: 220 mg/dl, prothrombin time: 40 seconds, and
urine output: 90 ml/min.
(b) What is the cause for oedema in this case?
(c) Explain the reasons for hypercholesterolemia.
(d) Discuss why there is an increase in prothrombin time.
4. What are the important roles of a doctor in a primary health centre? 5
(a) Enzymes used for diagnosis
(b) Synthesis of prostaglandins and inhibitors of their synthesis
c) Rapaport Leubering cycle and its significance
d) Energy production in anaerobic and aerobic glycolysis
d) LDL cholesterol and its role in formation of atherosclerosis
g) Mechanism of action of ligand gated ion channels
6. Justify the following statements: 2x5=10
(a) TCA cycle is sometimes called a 'metabolic traffic circle'.
(c) Valinomycin acts as a mobile ion carrier.
(d) Glucagon and glucocorticoids increase gluconeogenesis.
(e) Lecithin sphingomyelin ratio is significant in respiratory distress syndrome.
*****
SS/MBBS-I/1st IA/ BIO /08-24
2024
(August)
BIOCHEMISTRY
--- Content provided by FirstRanker.com ---
Paper-IFull Marks: 90
Time: 2 hours 50 minutes
The figures in the margin indicate
full marks for the questions
--- Content provided by FirstRanker.com ---
Answer all questions1. Describe the levels of organization of protein structure. Enumerate the
functions of protein in the human body. Write briefly about the structure-
function relationship of protein with special reference to haemoglobin.
[6 + 5 + 4 = 15]
--- Content provided by FirstRanker.com ---
2. Describe -oxidation of even-numbered fatty acid with its energetics. Add anote on disorders associated with it. What is the significance of -oxidation?
[(6 + 3) + 3 + 3 = 15]
3. A 5-year-old boy was admitted to the paediatric ICU with complaints of
weakness, fatigability, generalized body swelling, and decreased urinary
--- Content provided by FirstRanker.com ---
output. Initially, the swelling started around the eyes and later progressed tothe whole body. His blood sample was sent for investigations. The laboratory
report revealed--Total proteins: 5 g/dl, albumin: 2 g/dl, globulin: 3 g/dl, total
cholesterol: 400 mg/dl, LDL: 220 mg/dl, prothrombin time: 40 seconds, and
urine output: 90 ml/min.
--- Content provided by FirstRanker.com ---
(a) Mention the probable diagnosis.(b) What is the cause for oedema in this case?
(c) Explain the reasons for hypercholesterolemia.
(d) Discuss why there is an increase in prothrombin time.
4. What are the important roles of a doctor in a primary health centre? 5
--- Content provided by FirstRanker.com ---
5. Write short notes on the following: 5x7=35(a) Enzymes used for diagnosis
(b) Synthesis of prostaglandins and inhibitors of their synthesis
c) Rapaport Leubering cycle and its significance
d) Energy production in anaerobic and aerobic glycolysis
--- Content provided by FirstRanker.com ---
e) Short-term and long term complications of diabetes mellitusd) LDL cholesterol and its role in formation of atherosclerosis
g) Mechanism of action of ligand gated ion channels
6. Justify the following statements: 2x5=10
(a) TCA cycle is sometimes called a 'metabolic traffic circle'.
--- Content provided by FirstRanker.com ---
(b) Statins are used for lowering blood cholesterol levels.(c) Valinomycin acts as a mobile ion carrier.
(d) Glucagon and glucocorticoids increase gluconeogenesis.
(e) Lecithin sphingomyelin ratio is significant in respiratory distress syndrome.
*****
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24SM-1980/54Q SS/MBBS-I/BIOCHEM-I/08-24