Total No. of Printed Pages - 3
SS/MBBS-I/BIOCHEM-II /08-24
2024
(August)
BIOCHEMISTRY
Full Marks: 90
Time: 2 hours 50 minutes
The figures in the margin indicate
full marks for the questions
1. Define cancer and enumerate the causes of cancer. Discuss alteration in cell
cycle regulation in cancer with examples. Name the tumour marker for ovarian
and breast cancer. [2 + 5 + 6 + 2 = 15]
2. What are the proximate principles of a diet? How do you calculate a
sedentary habits. [5 + 6 + 4 = 15]
3. A 52-year-old alcoholic male presented with severe pain in his wrists and
right big toe, which was accompanied by inflammation and erythema of the
joints. On investigation, his serum uric acid level was > 10.5 mg/dl.
(a) What is the probable diagnosis?
(b) Enumerate the primary and secondary causes for the condition.
(c) What is the relationship between alcohol and the symptoms in this case?
(d) What are the treatment modalities in this case?
5. Write short notes on the following: [5x7=35]
(a) Cell-mediated immunity and its components
(b) Haemoglobin S disease and its complications
(c) Thyroid function tests and their significance
application
e) Role of transcriptional regulation of gene expression
f) Role of telomerase in health and disease
g) Homeostasis of blood calcium level
(a) Cyanide is an inhibitor of ETC.
(b) Photometric principle is used in analyzers of a clinical biochemistry lab.
(c) Biotransformation of toxic xenobiotics serves as an important defense
mechanism.
(e) Folate is trapped when vitamin B12 is deficient.
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24SM--1980/55Q SS/MBBS-I/BIOCHEM-II/08-24
SS/MBBS-I/BIOCHEM-II /08-24
2024
(August)
BIOCHEMISTRY
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Paper-IIFull Marks: 90
Time: 2 hours 50 minutes
The figures in the margin indicate
full marks for the questions
--- Content provided by FirstRanker.com ---
Answer all questions1. Define cancer and enumerate the causes of cancer. Discuss alteration in cell
cycle regulation in cancer with examples. Name the tumour marker for ovarian
and breast cancer. [2 + 5 + 6 + 2 = 15]
2. What are the proximate principles of a diet? How do you calculate a
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balanced diet? Prepare a balanced diet chart for a normal young adult male ofsedentary habits. [5 + 6 + 4 = 15]
3. A 52-year-old alcoholic male presented with severe pain in his wrists and
right big toe, which was accompanied by inflammation and erythema of the
joints. On investigation, his serum uric acid level was > 10.5 mg/dl.
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[1+4+2+3=10](a) What is the probable diagnosis?
(b) Enumerate the primary and secondary causes for the condition.
(c) What is the relationship between alcohol and the symptoms in this case?
(d) What are the treatment modalities in this case?
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4. Why should a good physician be a lifelong learner? 55. Write short notes on the following: [5x7=35]
(a) Cell-mediated immunity and its components
(b) Haemoglobin S disease and its complications
(c) Thyroid function tests and their significance
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(d) Molecular tools employed in recombinant DNA technology and its clinicalapplication
e) Role of transcriptional regulation of gene expression
f) Role of telomerase in health and disease
g) Homeostasis of blood calcium level
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6. Justify the following statements: [2x5=10](a) Cyanide is an inhibitor of ETC.
(b) Photometric principle is used in analyzers of a clinical biochemistry lab.
(c) Biotransformation of toxic xenobiotics serves as an important defense
mechanism.
--- Content provided by FirstRanker.com ---
(d) Bicarbonate is called the alkali reserve of plasma.(e) Folate is trapped when vitamin B12 is deficient.
*******
24SM--1980/55Q SS/MBBS-I/BIOCHEM-II/08-24
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