2024
(March)
PATHOLOGY
Paper-I
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Full Marks: 100Time: 3 hours
The figures in the margin indicate full marks for the questions
Answer all questions
1. Define apoptosis. What are the morphologic features of apoptosis?
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Enumerate the difference between apoptosis and necrosis. 2+3+3=82. A 60-year-old female recently operated for abdominal hernia, attends the
OPD with severe abdominal pain and reappearance of the swelling after an
episode of severe coughing. Her vitals we
re normal. 1+3+4=8
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(a) What is your probable diagnosis?(b) Describe the stages of wound healing.
(c) Differentiate between healing by first intention and healing by second
intention.
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3. Write short notes on the following: 5?8=40(a) Cellular events of inflammation
(b) Mechanism of cell injury
(c) Hazards of blood transfusion
(d) Intracellular accumulations
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(e) Classify Hodgkin's lymphoma.(f) "Tp53 : Guardian of the genome." Elaborate.
(g) Describe the diagnostic role of cytology and its application in clinical care.
(h) Describe the role of justice as a guiding principle in patient care.
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4. Answer in short: 2?9=18(a) Special stains to demonstrate amyloid
(b) Tigered effect
(c) Four indications of bone marrow aspiration
(d) Define metaplasia and dysplasia.
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(e) Paradoxical emboli(f) Name two stains used to diagnose myeloid neoplasm.
(g) Define granuloma.
(h) Disorder caused by air pollution
(i) H. pylori associated tumour
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5. Define anaemia. Write the aetiopathogenic classification of anaemia.Enumerate the investigations in a case of megaloblastic anaemia. 2+3+3=8
6. A 54 year-old female presented in the OPD with backache and weakness.
Radiological studies revealed bony lytic lesions over the vertebrae. Laboratory
studies showed increased M protein in serum, elevated creatinine and calcium
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level. 1+4+3=8(a) What is your probable diagnosis?
(b) Describe the pathogenesis of the condition.
(c) Describe the peripheral blood and bone marrow picture.
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7. Choose the correct answer: 1?10=10(i) Reticulocyte count is decreased in
- (a) iron-deficiency anaemia
- (b) aplastic anaemia
- (c) megaloblastic anaemia
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- (d) haemolytic anaemia(ii) Bernard-Soulier syndrome is a defect in
- (a) platelet aggregation
- (b) platelet adhesion
- (c) platelet release reaction
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- (d) platelet morphology(iii) Diabetic foot is an example of
- (a) gas gangrene
- (b) dry gangrene
- (c) wet gangrene
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- (d) necrotizing inflammation(iv) Cerebral plaques in Alzheimer's disease consist of
- (a) ATTR protein
- (b) A protein
- (c) A protein
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- (d) prion protein(v) Haemophilia is
- (a) X-linked recessive
- (b) autosomal dominant
- (c) autosomal recessive
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- (d) X-linked dominant(vi) Bitot's spot is found in deficiency of
(a) vitamin D
(b) vitamin K
(c) vitamin A
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(d) vitamin E(vii) Formation of granuloma is
(a) type I hypersensitivity reaction
(b) type II hypersensitivity reaction
(c) type III hypersensitivity reaction
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(d) type IV hypersensitivity reaction(viii) Hepar lobatum is seen in
(a) primary syphilis
(b) secondary syphilis
(c) tertiary syphilis
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(d) congenital syphilis(ix) In iron-deficiency anaemia, TIBC is
(a) low
(b) normal
(c) high
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(d) borderline
x) Pappenheimer bodies represent
(a) DNA
(b) RNA
(c) non-haem iron
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(d) mitochondria*****