SS/MBBS-II/PHAR-I/03-24
2024
(March)
PHARMACOLOGY
Paper-I
Time: 3 hours
The figures in the margin indicate full marks for the questions
Answer all questions
1. Choose the appropriate answer from the choices given below : 1?10=10
(a) spironolactone
(b) rifampicin
(c) penicillin
(d) bumetanide
(a) hypokalemia
(b) hyponatremia
(c) hyperglycaemia
(d) hypocalcemia
(a) Sublingual
(b) Intraarticular
(c) Oral
(d) Intravenous
(a) Latanoprost
(b) Phenylephrine
(c) Atropine
(d) Pilocarpine
(a) it causes down regulation of beta 2 receptor on prolonged use
(b) it causes ankle oedema
(c) it acts better on the receptors of the larger airways than the receptors of
bronchioles
(vi) All of the following nutraceuticals contribute to cartilage health, except
(a) glucosamine
(b) chondroitin sulfate
(c) diacerein
(vii) Most common indication for therapeutic monitoring is
(a) hit and run drugs
(b) drugs with irreversible action
(c) narrow therapeutic range
(d) failure of response
(viii) Actions of adrenaline include all, except
(a) bronchoconstriction
(b) increased force of contraction
(c) increased heart rate
(ix) Which of the following antihypertensives is not given in pregnancy?
(a) Enalapril
(b) -Methyldopa
(c) Labetalol
(x) Which is not true of clinical trials?
(a) Safety is the primary concern
(b) Efficacy is the primary concern
(c) The 4th phase of trial is carried out post-marketing
clinical trials
2. Name oral and parenteral anticoagulants. What are their mechanisms of
anticoagulant effect? What are their adverse effects in overdose and what are
their specific antidotes? 3+4+3=10
uses and adverse effects of organic nitrates (Glyceryl trinitrate). 3+3+2+2=10
4. Write short notes on the following : 5?4=20
(a) Role of leukotriene antagonist in bronchial asthma
(c) Furosemide
(d) Clinical importance of microsomal enzyme induction
5. Classify drug receptors. Write the transducer mechanism of intracellular
receptors. Give one example of cytosolic and nuclear receptors. 3+5+2=10
(a) Urine alkalizer is given in barbiturate poisoning
(b) Ramipril can cause persistent brassy cough in susceptible individuals
(c) Concomitant use of salicylates increases warfarin toxicity
(d) An amphetamine addict likes to take NaHCO as well
7. Mr. Choudhury, a 45-year-old patient of cirrhosis of liver with oedema,
attended hospital for his treatment. Both loop diuretics and thiazide diuretics
failed to control oedema when used individually. (2+2)+2+2+2=10
(a) Explain why these two diuretics failed to respond. Which diuretic is to be
(b) Can acetazolamide be used in this case? Justify.
(c) What adverse effects the patient may develop if your choice of diuretic is
continued for prolonged period in this patient? Explain your answer.
(d) Why is the diuretic effect of furosemide blunted by indomethacin?
(a) First-order kinetics and zero-order kinetics
(b) Dietary supplements and nutraceuticals
(c) Hyoscine and scopolamine
(d) Adrenaline and Noradrenaline
9. Describe the role of beneficence as a guiding principle in patient care.
5
*****
2024
(March)
PHARMACOLOGY
Paper-I
--- Content provided by FirstRanker.com ---
Full Marks: 100Time: 3 hours
The figures in the margin indicate full marks for the questions
Answer all questions
1. Choose the appropriate answer from the choices given below : 1?10=10
--- Content provided by FirstRanker.com ---
(i) Drug causing gynaecomastia is(a) spironolactone
(b) rifampicin
(c) penicillin
(d) bumetanide
--- Content provided by FirstRanker.com ---
(ii) Thiazide diuretics cause all of the following, except(a) hypokalemia
(b) hyponatremia
(c) hyperglycaemia
(d) hypocalcemia
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(iii) Which of the following is a local route of drug administration?(a) Sublingual
(b) Intraarticular
(c) Oral
(d) Intravenous
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(iv) Which drug is contraindicated in glaucoma?(a) Latanoprost
(b) Phenylephrine
(c) Atropine
(d) Pilocarpine
--- Content provided by FirstRanker.com ---
(v) All are true of salbutamol, except(a) it causes down regulation of beta 2 receptor on prolonged use
(b) it causes ankle oedema
(c) it acts better on the receptors of the larger airways than the receptors of
bronchioles
--- Content provided by FirstRanker.com ---
(d) it can be given by inhalational route also(vi) All of the following nutraceuticals contribute to cartilage health, except
(a) glucosamine
(b) chondroitin sulfate
(c) diacerein
--- Content provided by FirstRanker.com ---
(d) PUFA(vii) Most common indication for therapeutic monitoring is
(a) hit and run drugs
(b) drugs with irreversible action
(c) narrow therapeutic range
--- Content provided by FirstRanker.com ---
(d) failure of response
(viii) Actions of adrenaline include all, except
(a) bronchoconstriction
(b) increased force of contraction
(c) increased heart rate
--- Content provided by FirstRanker.com ---
(d) calorigenesis(ix) Which of the following antihypertensives is not given in pregnancy?
(a) Enalapril
(b) -Methyldopa
(c) Labetalol
--- Content provided by FirstRanker.com ---
(d) Nifedipine(x) Which is not true of clinical trials?
(a) Safety is the primary concern
(b) Efficacy is the primary concern
(c) The 4th phase of trial is carried out post-marketing
--- Content provided by FirstRanker.com ---
(d) The principles of good clinical practice are to be followed in conductingclinical trials
2. Name oral and parenteral anticoagulants. What are their mechanisms of
anticoagulant effect? What are their adverse effects in overdose and what are
their specific antidotes? 3+4+3=10
--- Content provided by FirstRanker.com ---
3. Classify the antianginal drugs. Explain the mechanism of action, therapeuticuses and adverse effects of organic nitrates (Glyceryl trinitrate). 3+3+2+2=10
4. Write short notes on the following : 5?4=20
(a) Role of leukotriene antagonist in bronchial asthma
--- Content provided by FirstRanker.com ---
(b) Uses of alpha-blockers(c) Furosemide
(d) Clinical importance of microsomal enzyme induction
5. Classify drug receptors. Write the transducer mechanism of intracellular
receptors. Give one example of cytosolic and nuclear receptors. 3+5+2=10
--- Content provided by FirstRanker.com ---
6. Explain why : 2?5=10(a) Urine alkalizer is given in barbiturate poisoning
(b) Ramipril can cause persistent brassy cough in susceptible individuals
(c) Concomitant use of salicylates increases warfarin toxicity
(d) An amphetamine addict likes to take NaHCO as well
--- Content provided by FirstRanker.com ---
(e) Atropine is not given in narrow angle glaucoma7. Mr. Choudhury, a 45-year-old patient of cirrhosis of liver with oedema,
attended hospital for his treatment. Both loop diuretics and thiazide diuretics
failed to control oedema when used individually. (2+2)+2+2+2=10
(a) Explain why these two diuretics failed to respond. Which diuretic is to be
--- Content provided by FirstRanker.com ---
used in this case and why?(b) Can acetazolamide be used in this case? Justify.
(c) What adverse effects the patient may develop if your choice of diuretic is
continued for prolonged period in this patient? Explain your answer.
(d) Why is the diuretic effect of furosemide blunted by indomethacin?
--- Content provided by FirstRanker.com ---
8. Distinguish between : 3?5=15(a) First-order kinetics and zero-order kinetics
(b) Dietary supplements and nutraceuticals
(c) Hyoscine and scopolamine
(d) Adrenaline and Noradrenaline
--- Content provided by FirstRanker.com ---
(e) Labetalol and Metoprolol9. Describe the role of beneficence as a guiding principle in patient care.
5
*****
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