Download OU Pharm D Question Paper 1st Year 2018 1103 Pharmaceutical Organic Chemistry

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Code No. 1103

FACULTY OF PHARMACY

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Pharm. D (6 YDC) I-Year (Instant) Examination, March 2018

Subject : Pharmaceutical Organic Chemistry

Time : 3 Hours Max. Marks: 70

Note: Answer all questions from Part — A, answer any five questions from Part-B.

PART - A (10 x 2 = 20 Marks)

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1. Define electrophile with examples.
2. Write the structural formula for the following:
   1. 2-ethyl -1-methyl butane
   2. 2 — hydroxyl-4-pentanone
3. Define Baye’s strain theory.

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4. Why chlorobenzene undergoes electrophonic?
5. Why acetic acid is stronger than ethanol?
6. Write the structure and medicinal uses of the following:
   1. Dimercaprol
   2. Lactic acid

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7. Why phenols are much more acidic than alcohols?
8. Write about Wittig Reaction.
9. Describe the various rules governing Resonance.
10. Define free radicals with examples.

PART - B (5 x 10 = 50 Marks)

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11. Define free radical substitution reaction. Explain the mechanism of halogenations of alkanes.
12. Explain a note on E1 and E2 mechanism.
13. Explain the following:
    1. Markovnikov’s addition
    2. Free radical addition

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14. Explain in detail about acyl substitution reaction with four examples.
15. Describe the mechanism and stereochemistry of S_N1 reaction.
16. Write the reaction and mechanism of
    1. Cannizaro reaction
    2. Reformatsky reaction

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17. Write the structure, preparation, assay and uses of the following:
    1. Aspirin
    2. Saccharin sodium
18. Explain the following:
    1. Basicity of amines
    2. Benzoin condensation

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