Download OU Pharm D Question Paper 1st Year 2018 1240 Pharmaceutical Organic Chemistry

Download OU (Osmania University) Pharm D (Doctor of Pharmacy) 1st Year 2018 1240 Pharmaceutical Organic Chemistry Previous Question Paper

OU - 1701 OU - 1701
Code No. 1240
FACULTY
Pharm D (6?YDC)I ? Year (Main / Backlog) Examination, July 2018
Subject: Pharmaceutical Organic Chemistry
Time: 3 Hours Max.Marks: 70
Note: Answer all questions from Part ? A. Any Five questions from Part ? B.
PART ? A (10x2 = 20 Marks)
1 Write the IUPAC name of the following:
a)
|| ||
3 2
O O
CH - C- CH - C- OH
b)
| |
3
2 3
CH
Br 3
CH - CH - C H- CH - CH
2 Give the structural formula of:
a) But-1-en-3-yne
b) 1-Bromo-2-chloro ethane
3 Define the term acidity and basicity.
4 Explain polarity of molecules with example.
5 Explain activating and deactivating groups with example.
6 Arrange the following in decreasing order of their reactivity.
Benzene, Toluene and Nitrobenzene.
7 What is resonance? Give any two example.
8 Write any one method of preparation of lactic acid.
9 Explain hydrogen bonding with example.
10 Explain the acidity of phenol.
PART ? B (5x10 = 50 Marks)
11 a) Explain in detail the mechanism, stereochemistry and rearrangement reaction of
SN
1
with suitable example. 6
b) Explain the mechanism of free radical reaction of methane. 4
12 a) Explain the nucleophilic addition reactions of aldehyde. 5
b) Describe the methods of preparation of acid derivatives. 5
13 Write short notes on the following:
a) Reimer ? Tieman?s reaction 5
b) Williamson?s synthesis 5
..2
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OU - 1701 OU - 1701
Code No. 1240
FACULTY
Pharm D (6?YDC)I ? Year (Main / Backlog) Examination, July 2018
Subject: Pharmaceutical Organic Chemistry
Time: 3 Hours Max.Marks: 70
Note: Answer all questions from Part ? A. Any Five questions from Part ? B.
PART ? A (10x2 = 20 Marks)
1 Write the IUPAC name of the following:
a)
|| ||
3 2
O O
CH - C- CH - C- OH
b)
| |
3
2 3
CH
Br 3
CH - CH - C H- CH - CH
2 Give the structural formula of:
a) But-1-en-3-yne
b) 1-Bromo-2-chloro ethane
3 Define the term acidity and basicity.
4 Explain polarity of molecules with example.
5 Explain activating and deactivating groups with example.
6 Arrange the following in decreasing order of their reactivity.
Benzene, Toluene and Nitrobenzene.
7 What is resonance? Give any two example.
8 Write any one method of preparation of lactic acid.
9 Explain hydrogen bonding with example.
10 Explain the acidity of phenol.
PART ? B (5x10 = 50 Marks)
11 a) Explain in detail the mechanism, stereochemistry and rearrangement reaction of
SN
1
with suitable example. 6
b) Explain the mechanism of free radical reaction of methane. 4
12 a) Explain the nucleophilic addition reactions of aldehyde. 5
b) Describe the methods of preparation of acid derivatives. 5
13 Write short notes on the following:
a) Reimer ? Tieman?s reaction 5
b) Williamson?s synthesis 5
..2
OU - 1701 OU - 1701
Code No. 4253
-2-
14 Write the mechanism of:
a) Benzoin condensation 5
b) Reformatsky reaction 5
15 Write the ?test for purity? and uses for tartaric acid and glyceryl trinitrate. 10
16 a) Give 3 methods for the preparation of cyclopropane. 5
b) Explain in detail about bimolecular displacement mechanism. 5
17 a) Explain the mechanism of sulphonation reaction of benzene. 5
b) Explain in detail the effect of halogen on electrophilic aromatic substitution in alkyl
benzene. 5
18 a) Write the preparation and assay method of vanillin and dimercaprol. 5
b) Write the principle involved in the assay of aspirin. 5
****
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