Download OU Pharm D Question Paper 1st Year 2016 6115 Pharmaceutical Organic Chemistry

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Code No. 6115

FACULTY

Pharm D (6 - YDC) I - Year (Main / Backlog) Examination, August 2016

Subject: Pharmaceutical Organic Chemistry

Time: 3 Hours Max.Marks: 70

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Note: Answer all questions from Part — A. Any Five questions from Part - B.

PART - A (10x2 = 20 Marks)

1. Write the IUPAC name of the following:
   a) CH₃—C=CH - CH =CH₂
   b) CH₃—C—-CH₂-C - CH₃
   

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2. Give the step involved in the conversion of aniline into para-nitro aniline.
3. Give the structure formula of
   a) Methyl-1-penten-4-yne
   b) 5-Hydroxy-3-hexenal

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4. Comment on ethanol and dimethyl ether are isomer, but differ in the boiling point.
5. Briefly explain Bayer’s strain theory.
6. Write the different between S_N1 and S_N2.
7. Explain Saytzeff rule.
8. Classify each of the following-nucleophil or electrophil
   

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   1) NH₃ 2)H⁺ 3)CN^- 4) Cl⁺
9. Predict the product
   i) CH₃—CH = CH₂ +HBr ^Peroxide
   ii) CH₃— CH = CH₂ + HBr ^No-Peroxide
10. Explain Cannizzaro reaction.

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PART - B (5x10 = 50 Marks)

1. Explain the nucleophillic substitution reaction with Mechanism. 10
2. Explain with mechanism: 10
   i) Aldol-condensation
   ii) Sandmeyer’s reaction

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3. Define rearrangement reaction. Explain mechanism of following reaction.
   i) Fries rearrangement reaction
   ii) Hoffman rearrangement reaction. 10
4. Explain the mechanism of electrophillic substitution reaction taking a suitable example. 10
5. Write the short notes on:
   

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   i) Resonance concept
   ii) Acid-Base theory. 10
6. Explain mechanism involved in following reaction:
   i) Kolbe reaction
   ii) Michael addition 10

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7. a) Explain Friedel-Craft Alkylation reaction and write its drawback.
   b) Write a note on activating and deactivating O, P and M directing group.
8. a) Explain diazo-coupling reaction with mechanism.
   b) Write a note on elimination reaction:

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