Code No. 1117
FACULTY OF PHARMACY
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Pharm. D (6 YDC) Il - Year (Instant) Examination, March 2018
Subject: Medicinal Chemistry
Time: 3 Hrs Max. Marks: 70
Note: Answer all questions from Part - A and answer any five questions from Part-B.
PART - A (10 x 2 = 20 Marks)
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- Give two structural examples of Macrolide antibiotics.
- Explain the mechanism of action of organic nitrates as antianginal agents with examples.
- Give two examples and therapeutic uses of Disinfectant.
- Mention the applications of ASAR.
- Write two examples of anti-inflammatory glucocorticoids.
- Write the name and structure of drug used as anticonvulsant and antiarrhythmic agent.
- Write the structure and uses of chloramphenicol.
- Mention the classification of prodrugs.
- Explain the mechanism of action and uses of ACE inhibitors.
- Give the applications of Diagnostic agents.
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PART -B (5 x 10 = 50 Marks)
- (a) Give the classification of antihypertensive agents giving two examples for each class.
(b) Explain SAR and mode of action of thiazide diuretics. - Outline the synthesis and uses of
(a) Cloridine--- Content provided by FirstRanker.com ---
(b) Tinidazole - (a) Write the classification of antitubercular drugs giving one structural example for each class
(b) Discuss about plant products used as antineoplastic agents. - Write the synthesis, mode of action and uses of
(a) Diltiazem--- Content provided by FirstRanker.com ---
(b) Chloroquine Phosphate - (a) Explain SAR and mechanism of action of penicillins.
(b) Write a note on anti AIDS agents. - (a) Write the classification of antifungal agents giving two examples for each class
(b) Write a note on Androgens. - Outline the synthesis mode of action and therapeutic uses of
(a) Clofibrate
(b) Furosemide
(c) Sulfamethoxazole - Give a brief note on
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(a) Combinational chemistry
(b) Loop Diuretics.
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