Download OU Pharm D Question Paper 3rd Sem 2020 6191 Medicinal Chemistry

Download OU (Osmania University) Pharm D (Doctor of Pharmacy) 3rd Year (3rd Semester) 2020 6191 Medicinal Chemistry Previous Question Paper

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Code No. 6191
FACULTY OF PHARMACY
Pharm. D (6 YDC) III-Year (Instant) Examination, February 2020

Subject : Medicinal Chemistry
Time : 3 Hrs Max. Marks: 70

Note: Answer all questions from Part ? A, answer any five questions from Part-B.

PART ? A (10 x 2 = 20 Marks)
1 What is CADD? What are its advantages?
2 Write the synthesis of Isoniazid.
3 Define Antibiotics. Write the mechanism of action of aminoglycoside antibiotics.
4 What are antihelminthics? Give examples.
5 Draw the structures of : (a) Cortisone (b) Hydrocortisone
6 Explain epimenization reaction in tetracyclines.
7 Write the degradation reactions of Penicillins.
8 What are Coagulants? Give the examples with structures.
9 Write the brand names of the following drugs.
(a) Amoxacillin + clavulanic acid (b) Cefpodoxiome
10 Define antiseptics and disinfectants with examples.

PART ? B (5 x 10 = 50 Marks)
11 What is combinatorial synthesis? Explain in detail the essential requirements of
solid phase synthesis. (10)

12 (a) Give the classification of antihypertensives. (5)
(b) Write the mode of action and SAR of ACE inhibitors. (5)

13 Classify Antitubercular. Write the mechanism of action of each class of drugs. (5+5)

14 (a) Write the mechanism of action and SAR of (5)
(i) Statins (ii) Fibrates
(b) Write the Synthesis of : (5)
(i) Hydrochlorthiazide (ii) Furosemide

15 (a) Write the mode of action, SAR and uses of penicillin. (6)
(b) Give the synthesis of clofibrate and clonidine (4)

16 What is prodrug? What are the types of prodrug? Explain in detail its applications
along with examples.

17 (a) Classify antiviral drugs with examples. (5)
(b) Write the mechanism of action of : (5)
(i) loop diuretics (ii) Thiazide diuretics

18 (a) Classify antianginal agents with examples. (5)
(b) Write the synthesis and mode of action (5)
(i) Ketoconazole (ii) Ethambutol

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