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Code No. 13301
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FACULTY OF PHARMACY
Pharm D (6 - YDC) V - Year (Main & Backlog) Examination, June 2019
Subject: Clinical, Pharmacokinetics & Pharmacotherapeutic Drug Monitoring
Time: 3 Hrs Max.Marks: 70
Note: Answer all questions from Part — A. Any Five questions from Part - B.
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PART - A (10x2 = 20 Marks)
- Write the importance of nomograms in designing of dosage regimen.
- What is TDM? Write the indications for TDM.
- Add a note on PK-PD correlation in drug therapy.
- Write a note on Cyp-450 enzymes.
- Write the significance of half life in clinical pharmacokinetics.
- Explain enzyme induction with examples.
- What are the methods involved in the conversion of IV to oral dose?
- Write the TDM of digoxin.
- Give two examples of genetic polymorphism in drug transport.
- Write the importance of bioavailability in pharmacokinetics.
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PART - B (5x10 =50 Marks)
- Explain in detail about the dosage adjustment in patients with hepatic disease.
- Write a note on:
- Bayesian theory
- Analysis of population pharmacokinetic data.
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- Describe the role of genetic polymorphism in drug action.
- Explain in detail about individualization of drug dosage regimen.
- Write in detail about various pharmacokinetic drug-drug interactions with suitable examples.
- Describe in detail about
- Dosage adjustment in obese patients.
- TDM of carbamazepine and phenytoin sodium.
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- Explain in detail the extra corporeal removal of drugs.
- Describe the general approach for dosage adjustment in renal disease.
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