Download OU Pharm D Question Paper 5th Sem 2020 6202 Clinical Pharmacokinetics And Pharmacotherapeutic Drug Monitoring

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Code No. 6202

FACULTY OF PHARMACY

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Pharm D (6 - YDC) V - Year (Instant) Examination, February 2020

Subject: Clinical Pharmacokinetics & Pharmacotherapeutic Drug Monitoring

Time: 3 Hrs Max.Marks: 70

Note: Answer all questions from Part — A. Any Five questions from Part - B.

PART - A (10x2 = 20 Marks)

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1. Write about determination of dose and dosing interval.
2. Write the TDM for phenytoin sodium.
3. Explain about insulin clearance.
4. Write a note on enzyme inhibition with examples.
5. Add a note on Biliary Excretion.

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6. Give a brief account on dosage adjustment in uremic patients
7. Brief about pharmacogenetics and its applications.
8. Write a brief note on dosing with feedback.
9. What is the role of pharmacist in clinical pharmacokinetics?
10. Write the significance of population pharmacokinetics.

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PART - B (5x10 =50 Marks)

11. Describe the following:
    1. Pharmacokinetic correlation in drug therapy. [5]
    2. Bayesian theory [5]
12. Explain in detail about the role of genetic polymorphism in drug metabolism and target with examples. [10]

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13. 1. Explain various diseases where TDM is applicable. [4]
    2. Dosage variability: with respect to genetics, disease and age. [6]
14. Write a note on drug dosing in elderly and pediatric patients. [10]
15. Add a note on:
    1. Induction of drug metabolism. [5]

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    2. Dosage adjustment in hepatic disease. [5]
16. Explain various pharmacokinetic drug -drug interactions with suitable examples. [10]
17. Explain about the following:
    1. GFR and creatinine clearance. [5]
    2. Adaptive method with feedback. [5]

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18. Write in brief about clinical pharmacokinetics. [10]