Code No. 4277
FACULTY OF PHARMACY
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Pharm. D (6 YDC) V-Year (Main) Examination, July 2017
Subject : Clinical Pharmacokinetics and Pharmacotherapeutic Drug Monitoring
Time : 3 Hrs Max. Marks: 70
Note: Answer all questions from Part - A and answer any five questions from Part-B.
PART - A (10 x 2 = 20 Marks)
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- What is the role of pharmacist in clinical pharmacokinetics?
- Write the significance of population pharmacokinetics.
- What are the major considerations in TDM?
- What are the main factors that influence drug design in renal disease?
- Why is creatinine clearance difficult to predict? Explain.
- Define pharmacogenetics and write its applications.
- Write the TDM for carbamazepine.
- What are the pharmacokinetic considerations in designing a dosage regime?
- Write a note on pharmacokinetic drug — drug interactions with suitable examples.
- Write any one method dosage conversion from I.V. to oral dosing.
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PART - B (5 x 10 = 50 Marks)
- Explain TDM drugs used in cardiovascular and seizure disorders.
- (a) Explain different dosage adjustment for uremic patients.
(b) Write a note on effect of hepatic disease on pharmacokinetics. - Explain briefly Bayesian theory and analysis of population pharmacokinetic data.
- Explain the role of cytochrome p-450 isoenzyme in genetic polymorphism in drug metabolism.
- Explain the drug dosing in elderly, pediatrics and obese patients.
- Describe inhibition and induction of drug metabolism.
- Explain measurement of glomerular filtration rate and creatinine clearance.
- Explain how TDM will affect individualization of drug dosage Regime.
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This download link is referred from the post: OU Pharm D Question Papers Last 10 Years 2010-2020 || Osmania University
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