Download OU Pharm D Question Paper 5th Sem 2018 1127 Clinical Pharmacokinetics And Pharmacotherapeutic Drug Monitoring

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Code No. 1127

FACULTY OF PHARMACY

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Pharm. D (6 YDC) V-Year (Instant) Examination, March 2018

Subject : Clinical Pharmacokinetics and Pharmacotherapeutic Drug Monitoring

Time : 3 Hrs Max. Marks: 70

Note: Answer all questions from Part — A, answer any five questions from Part-B.

PART - A (10 x 2 = 20 Marks)

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1. What is TDM? Write the Indications for TDM.
2. Write a note on drug interactions at the elimination site.
3. Write about Cytochrome P -450 isoenzymes.
4. Write about the determination of Dose and Interval.
5. Explain enzyme induction with examples.

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6. Explain plasma protein binding with its significance.
7. Explain Biological half-life.
8. What are the factors involved in the conversion of Intra Venous to oral dosing?
9. What is Pharmacogenetics?
10. Write the TDM protocol for vancomycin.

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PART - B (5 x 10 = 50 Marks)

11. Explain the TDM for cardiovascular diseases.
12. Describe the pharmacodynamic drug interaction in detail.
13. Explain in detail about the dosage adjustment in patients with hepatic disease.
14. Write about Renal impairment. Write the importance of GFR and Creatinine clearance in dose adjustment.

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15. (a) Describe the Bayesian-theory:
    (b) Pharmacokinetic correlation in drug therapy.
16. Explain in detail genetic polymorphism in (a) Drug metabolism (b) Drug absorption
17. How do you fix the dose for Obese, pediatric and geriatric patients?
18. Explain the extracorporeal removal of drugs.

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