Download OU Pharm D Question Paper 5th Sem 2018 1264 Clinical And Pharmacokinetics Pharmacotherapeutic Drug Monitoring

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FACULTY OF PHARMACY

Pharm D (6-YDC) V-Year (Main & Backlog) Examination, July 2018

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Subject: Clinical & Pharmacokinetics Pharmacotherapeutic Drug Monitoring

Time: 3 Hrs Max.Marks: 70

Note: Answer all questions from Part — A. Any Five questions from Part - B.

PART - A (10x2 = 20 Marks)

1. What is the role of pharmacist in clinical pharmaceutics?

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2. What type of drugs should be monitored?
3. Why is creatinine clearance used in renal disease?
4. Write the TDM of digoxin.
5. Write the significance of population pharmacokinetics.
6. Write a note on indications for TDM.

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7. Write a note on effect of hepatic disease on pharmacokinetics.
8. Name and contrast any two methods adjusting drug dose in renal disease.
9. Write any one method of dosage conversion from IV to oral dosing.
10. Define pharmacogenetics and write its applications.

PART - B (50 Marks)

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11. Describe the effect of genetic polymorphism in drug transport and drug targets.
12. Explain TDM of drugs used in cardiovascular and organ transplantations.
13. Explain the drug dosing in elderly, pediatrics and obese patients.
14. Explain the measurement of glomerular filtration rate and creatinine clearance.
15. Explain various pharmacokinetic drug — drug interactions along with suitable examples.

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16. Write a note on protocols for TDM and explain how TDM will affect individualization of drug dosage regime.
17. a) Explain briefly extracorporeal removal of drugs.
    b) Write a note on dosage adjustment in renal disease.
18. Explain briefly Bayesian theory and analysis of population pharmacokinetic data.

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