Download GTU B.Tech 2020 Winter 5th Sem 3153601 Pharamceutical Chemistry Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY
BE- SEMESTER-V (NEW) EXAMINATION - WINTER 2020

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Subject Code:3153601 Date:01/02/2021
Subject Name: Pharmaceutical Chemistry
Time:10:30 AM TO 12:30 PM Total Marks: 56

Instructions:

1. Attempt any FOUR questions out of EIGHT questions.

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2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

MARKS

Q.1 (a) Define (1). Hyperglycemia, (2). Type-1 diabetes, (3). Type-2 03
diabetes

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(b) Write notes on (1). Oral Iron therapy, (2). Parenteral Iron therapy 04
(c) Write the chemical degradation of Penicillin with structures 07

Q.2 (a) What are hormones? Write the classification of hormones. 03
(b) Discuss any four guidelines for choosing a disconnection in 04
Retrosynthesis. Give suitable examples wherever required

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(c) Write the MOA, SAR of Sulphonyl urea class of antidiabetic drug. 07
Give one example and write the synthesis of it.

Q.3 (a) Write the general structure of (1).Penicillin,(2) Cephalosporin 03
(b) Write the disconnection of Cis(Z)-Jasmone (only disconnection). 04
Write the steps to get the correct regiochemistry & cis

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stereochemistry(structure given)

cis(Z) Jasmone
(c) What are (1). Synthons, (2). Retrosynthesis ? By disconnection 07
approach, suggest a scheme for synthesis of antituberculosis drug-

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para amino salicylic acid

Q.4 (a) Write the MOA of Penicillin antibiotics 03
(b) By disconnection ‘method write the synthesis of (1R, 2S)-(-)- 04
Ephedrine. Write the resolution procedure to get (1R, 2S)-(-)-
Ephedrine(structure given)

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OH H
N\CHg
CHs (1R,2S)(-)-Ephedrine

(c) By disconnection method, write the synthesis of (1). Propranolol, 07
(2). Bropirimine. (structures given)

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0 N\(
O _ (1).Propranolol
| (2). Bropirimine

Q.5 (a) Write the structure of Cholestane template and show how it is 03
numbered

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(b) Write the synthesis of Metronidazole- a drug molecule containing 04
imidazole heterocycle. (structure given)

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(c) Write the biosynthesis of sex hormones from Cholesterol 07

Q.6 (a) Write the structure (1). Pregn-4-ene-3,20-dione, (2). 17-beta 03

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hydroxy- androst-4-ene-3-one
(b) Write the synthesis of sedative Glutethimide- a drug molecule 04
containing piperidine heterocycle derivative. (structure given)

H
o N o

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(c) Write the SAR of Oestrogens 07

Q.7 (a) Define Hypothyroidism. Write one example with structure of 03
thyroid drug. Write its MOA
(b) Describe the roles of the three hormones in Calcium homeostasis 04
(c) By disconnection approach, write the synthesis of NSAID- 07

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Ibuprofen. (structure given)

O
HO

Q.8 (a) Define antithyroid drugs. Give two examples with structure. 03
(b) What are hormonal contraceptives? Write a note on oral 04

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contraceptives
(c) By disconnection approach, write the synthesis of antidepressant- 07
Venlafaxine. (structure given)

|
_N

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OH

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