Download GTU B.Pharma 2020 Winter 6th Sem 2260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry Ii) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Winter 6th Sem 2260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry Ii) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph- SEMESTER?VI ? EXAMINATION ? WINTER-2020
Subject Code: 2260004
Date: 11/01/2021
Subject Name: Pharmaceutical Chemistry ? VIII (Medicinal Chemistry ? II)
Time: 2:00 PM TO 4:00 PM
Total Marks: 54
Instructions:


1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 (a) Define and classify general anesthetics with example. Explain Structure activity 06
relationship of Benzodiazepines.

(b) Explain Structure activity relationship and mode of action of Tricyclic
05
antidepressants.

(c) Give synthesis of L-Dopa and Amphetamine.
05



Q.2 (a) Explain different theory of drug-receptor interactions in detail.
06

(b) Write a brief note on factors affecting drug- receptor interaction.
05

(c) Define Xenobiotics. Give importance of CYP-450 in drug metabolism
05



Q.3 (a) What is a CNS stimulant? Explain classification of CNS stimulants with
06
suitable example. Write a brief note on hallucinogenic agents.

(b) What is Parkinson's disease? Write a note on antiparkinson's agents.
05

(c) Give synthesis of Halothane and Lignocaine.
05



Q.4 (a) Define and classify local anesthetics. Explain the SAR of Barbiturates.
06

(b) Write a brief note on factors affecting drug metabolism.
05

(c) Give synthesis of Thiopental sodium and Phenobarbitone.
05



Q.5 (a) What is psychosis? Explain briefly about SAR for Phenothiazines.
06

(b) Write a brief note on antigout agents.
05

(c) Give synthesis of Fluoxetine and Imipramine.
05



Q. 6 (a) Explain Various forces involved in drug-receptor interaction.
06

(b) Explain briefly about SAR for Local anesthetic agents.
05

(c) Give synthesis of Chlordiazepoxide and Phenytoin.
05



Q.7 (a) Write a brief note on Phase-I and Phase-II metabolism in detail.
06
OR

(a) Write a brief note on Cognition enhancers.
06
OR

(a) Write synthesis of Mefenamic acid and Nimesulide.
06
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