Download GTU B.Pharma 2020 Winter 6th Sem 2260005 Pharmacology And Pharmacotherapeutics Ii Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY

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Instructions:

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1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

1. (a) Explain GABA as CNS neurotransmitter. 06
   

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   (b) Classify NSAIDs with examples. Explain the pharmacological actions and therapeutic uses of Aspirin. 05
   (c) Write a short note on: Stages of anaesthesia. 05
2. (a) Enumerate Affective disorders. Explain in brief signs and symptoms and diagnostic tests for depression. 06
   (b) Classify immunosuppressants. Write the mechanism of action, adverse effects and therapeutic uses of Ciclosporin. 05
   (c) Write a short note on: Pre- anaesthetic medications. 06

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3. (a) Discuss etiology, clinical signs and symptoms and pathophysiology of Parkinsonism. Explain why levodopa is given in combination with carbidopa in treatment of Parkinsonism. 05
   (b) Discuss the positive and negative symptoms of Psychoses or Schizophrenia. 05
   (c) Write a short note on: Drug dependance and abuse. 06
4. (a) Classify antiepileptic drugs acting through GABA giving brief mechanism of each class. What is status epilepticus? 05
   (b) Explain synthesis and metabolism of Uric acid. Discuss the mechanism of action of Colchicine and Probenacid in treatment of Gout. 05
   

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   (c) Write a short note on: Selective COX-II inhibitors. 06
5. (a) Explain the pathophysiology, clinical features and tests for diagnosis of Alzheimer’s disease. 05
   (b) What are Disease Modifying AntiRheumatic Drugs (DMARDs)? Give examples. Explain their role in treatment of Rheumatoid Arthritis. 05
   (c) Write a short note on: Morphine poisoning and its treatment. 06
6. (a) Define Anxiety. Give its etiology and signs and symptoms. Explain the role of Benzodiazepines in treatment of anxiety. 05
   

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   (b) Define Insomnia. Give its etiology and differentiate between REM and NREM sleep. 05
   (c) Write a short note on: Dopamine as CNS neurotransmitter. 06
7. (a) Discuss etiology, signs and symptoms and diagnosis of Rheumatoid Arthritis. 06
   OR
   Classify CNS stimulant drugs. Explain mechanism of action and therapeutic uses of Amphetamine. 06
   

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   OR
   Justify the use of:
   (1) Donepezil in treatment of Alzheimer’s disease.
   (2) Ethyl alcohol in treatment of methyl alcohol poisoning

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