Download GTU B.Pharma 2020 Winter 6th Sem BP601TP Medicinal Chemistry Iii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Winter 6th Sem BP601TP Medicinal Chemistry Iii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. ? SEMESTER VI ? EXAMINATION ? WINTER -2020
Subject Code: BP601TP
Date: 02/01/2021
Subject Name: Medicinal Chemistry III
Time: 02:00PM TO 04:00PM
Total Marks: 54
Instructions:


1. Attempt any THREE questions from Q-1 to Q-6.
2. Q.7 is compulsory to attempt.
3. Make suitable assumptions wherever necessary.
4. Figures to the right indicate full marks.

Q.1 (a) Classify cephalosporin. Write a note on monobactam.
06

(b) Define and classify prodrug with suitable examples.
05

(c) What is QSAR? Write a note on Hansch analysis.
05



Q.2 (a) What is combinatorial chemistry? Explain different methodologies used for
06
synthesis.

(b) Classify sulphonamides based on chemical structures. Outline synthesis of
05
sulphamethoxazole.

(c) Explain SAR of Sulphonamides.
05



Q.3 (a) Classify antitubercular agent. Give synthesis of Isoniazid.
06

(b) Write short notes on computer aided drug design.
05

(c) Describe SAR of quinolines. Explain mechanism of chloroquine.
05



Q.4 (a)
i.
Life cycle of malarial parasite
06
ii.
Macrolide antibiotic

(b) Write a note on applications of prodrug.
05

(c) Write IUPAC name and synthesis of the following drugs :
05
(i)
Miconazole (ii) Mebendazole



Q.5 (a) Give brief note on antiviral agents.
06

(b) Write the chemical degradation of penicillin with structures.
05

(c) Explain SAR of quinolones as antibacterial agent.
05



Q. 6 (a) Classify and explain mechanism of action of azole antifungal agents. Draw
06
structure of one drug from each class of it.

(b) Write uses and synthesis of the following drugs :
05
(i) Ciprofloxacin (ii) Acyclovir

(c) Draw general structure of tetracycline antibiotics. Explain mechanism of action
05
and side effects of it.



Q.7 (a)
i.
What is tissue amoebicide and luminal amoebicid? Give examples.
06
ii.
Outline the synthesis of metronidazole.
iii.
What is anthelmintic? Explain mechanism of benzimidazole as
anthelmintic.
OR

(a) Write a short note on aminoglycoside antibiotics.
06
OR

(a) Give IUPAC name and synthesis of the following drugs :
06
(i) Chloroquine (ii) Chloramphenicol
***************

---