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Seat No.: Enrolment No.
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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- VIII - EXAMINATION - WINTER -2020
Subject Code: 2280003 Date: 06/01/2021
Subject Name: Pharmaceutical Chemistry-X (Medicinal Chemistry-III)
Time: 02:00PM TO 04:00PM Total Marks: 54
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Instructions:
- Attempt any THREE questions from Q-1 to Q-6.
- Q.7 is compulsory to attempt.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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Q.1 (a) Define and classify Diuretic Agents. Discuss the SAR among Progestins and Androgens. 06
(b) Give the method of synthesis of (i) Lignocaine (ii) Atenolol 05
(c) Discuss the SAR among HMG CoA Reductase inhibitors. 05
Q.2 (a) What is Diabetes? Classify antidiabetics with examples and give their mechanism of action. 06
(b) Give SAR of ACE inhibitors. 05
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(c) Give the method of synthesis of (i) Acetazolamide (ii) Captopril 05
Q.3 (a) Give the method of synthesis of 06
(i) Warfarin (ii) Metformin (iii) Carbimazole.
(b) Discuss the SAR among 05
(i) Thiazide Diuretics (ii) 5 — Sulfamoyl Benzoic acid derivatives.
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(c) Discuss the SAR among 05
(i) Estrogens (ii) Dihydropyridines
Q.4 (a) Discuss the SAR among Cardiac glycosides. 06
(b) Write informative note on Anti platelet Agents. 05
(c) Discuss detail about plasma expanders. 05
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Q.5 (a) Explain in detail the nomenclature and stereochemistry of Steroidal Compounds. 06
(b) Write down notes on Coagulants and Anticoagulants. 05
(c) Write short notes on Thrombolytic agents. 05
Q.6 (a) Give the method of synthesis of 06
(i) Clofibrate (ii) Ethacrinic acid (iii) Glimipride
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(b) Define and classify Hypoglycemic Agents. 05
(c) Write short notes on Thrombolytic agents. 05
Q.7 (a) What are the causes of hypertension? Write a note on B-blockers. 06
OR
(a) What is obesity? Write a note on antiobesity drugs. 06
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OR
(a) Write detail note on Cardio tonic Agents. 06
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