Enrolment No
B.Pharm - SEMESTER-V EXAMINATION — WINTER -2020
Subject Code:2250003 Date: 07/01/2021
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Subject Name: Pharmaceutical Analysis-111
Time: 10:30AM TO 12:30PM Total Marks: 54
Instructions:
- Attempt any THREE questions from Q-1 to Q-6.
- Q.7 is compulsory to attempt.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
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Q.1 (a) Draw and predict the No of NMR signal of following compound 06
A) p-Xylene B) Ethanol C) Ethyl ethanoate D) Toluene E) Dioxane F) Allyl bromide
(b) Write a note on spin - spin coupling with example of Ethylchloride. 05
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(c) Discuss factors affecting chemical shift in NMR. 05
Q.2 (a) Predict the structure of given compound by given data. 06
Molecular weight: 72 amu
uv: 272 nm ( A max)
IR: 2941-2857(m), 1716(s), 1460(m) cm™
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NMR: (Delta Value) Quartet d =2.48(2H)
Singlet d=2.22(3H)
Triplet d=1.07(3H)
(b) Write short notes on any two with example (i) Mc-Lafferty rearrangement (ii) 05
Molecular ion peak (iii ) Fragmentation pattern of Alkene.
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(c) Define mass spectroscopy and give the principle with labeled diagram of mass 05
spectrometer
Q.3 (a) What is the energy of one photon having wavelength 600 nm 06
(Planck constant value:6.626 x 10-34 J* Sec)
(b) Draw a well labeled diagram of Spectrofluorimeter and Draw labeled jablonski 05
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diagram.
(c) Write short not on different type of Interference in AAS. 05
Q.4 (a) Justify the following comments. 06
- Fluorescence occurs at longer wavelength than absorbance radiation.
- Detector is placed at right angle to sample in flourimeter.
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(b) State and derive lambert beer law equation. 05
(c) Define BlueShift, Monochromator, Specral Interference, Chromophore and 05
Auxochrome.
Q.5 (a) How would you differentiate primary amine, Secondary amine and tertiary amine with 06
the help of fragmentation in MS?
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(b) Discuss constructions and working of FT-IR. 05
(c) Enlist detectors used in IR spectroscopy and write a note on any detector. 05
Q.6 (a) Draw schematic spectrum pattern of UV, IR, NMR, MS (With Axis) 06
(b) Write down the Application of Atomic absorption Spectroscopy. 05
(c) Discuss the wavelength, frequency and Energy term for electromagnetic Wave. 05
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Q.7 (a) What are the different types of vibration in Infrared Spectroscopy? What are the 06
possibilities if IR Spectra Shows one peak near to 1700 cm-1
OR
(a) Explain analysis of binary mixtures of absorbing substances by simultaneous equation (6
method.
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OR
(a) Enlist application of UV spectroscopy and explain any one in detail. 06
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