Download GTU B.Pharma 2020 Summer 4th Sem BP401TT Pharmaceutical Organic Chemistry Iii Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Summer 4th Sem BP401TT Pharmaceutical Organic Chemistry Iii Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. SEMESTER?IV ? EXAMINATION ? SUMMER -2020
Subject Code: BP401TT
Date: 26-10-2020
Subject Name: Pharmaceutical Organic Chemistry III
Time: 10:30 AM TO 1:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Draw structure of the following compounds.
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i) cis-3,4-dimethyl-3-heptene ii) trans-1,3-dichlorocyclobutane
iii) (R)-2-butanol iv) (RS)-2-chloro, 3-pentanol
v) cis- 2-chloro,3-bromo butene vi) (S)-3-chlorohexane

(b) Write note on stereochemistry of Biphenyls.
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(c) What is resolution? Explain the methods for racemic modification into
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enantiomers.



Q.2 (a) Define the following terms:
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(i) Configuration (ii) Geometric isomerism (iii) Enantiomer
(iv) Meso isomer (v) Chiral center (iv) Racemic mixture

(b) Explain the reactions of chiral molecule.
05

(c) Explain Clemmensen reduction with mechanism.
05



Q.3 (a) Explain partial and absolute asymmetric synthesis.
06

(b) Explain diastereomers and their properties with suitable example.
05

(c) Write in brief conformational analysis of n-Butane.
05



Q.4 (a) Discuss the Sequence rule to assign configuration with example.
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(b) Explain the stereospecific and stereoselective reactions.
05

(c) Give methods of determination of configuration of geometrical isomers.
05



Q.5 (a) Give the structure of:
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(1) Indole (2) Pyridine (3) Isoquinoline
(4) Imidazole (5) Acridine (6) Thiophene

(b) Explain Beckmann rearrangement reaction with mechanism.
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(c) Give synthesis and medicinal uses of Pyrimidine.
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Q. 6 (a) Give THREE reactions of the following:
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(1) Furan (2) Quinoline

(b) Write about Oppenauer oxidation.
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(c)
Comment on the following
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1. Pyridine is more basic than Pyrrole.
2. Pyridine is less basic than aliphatic amines.



Q.7 (a) Write a short note on the following.
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i) Skraup Quinoline synthesis
ii) Knorr pyrrole synthesis

(b) Explain metal hydride reduction by using different reagents.
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(c) Explain preparation and reactions of Pyridine.
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