Download GTU B.Pharma 2020 Summer 5th Sem 2250004 Pharmaceutical Chemistry Vii (Medicinal Chemistry I) Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER- 5 EXAMINATION - SUMMER -2020
Subject Code: 2250004 Date:28-10-2020
Subject Name: Pharmaceutical Chemistry — VII (Medicinal Chemistry - I)
Time: 2:30 PM TO 5:30 PM Total Marks: 80

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Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

1. (a) List out various physicochemical parameters. How hydrogen bonding and partition coefficient affects biological activity of drug. 06

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2. (b) Write a detailed note on bioisosterism with suitable examples. 05
3. (c) State and explain Ferguson principle. 05

1. (a) What is AChEIs? Describe mechanism of irreversible AChEIs with aging process. 06
2. (b) Explain neuromuscular blocking agents in detail. 05
3. (c) Give SAR of phenyl ethanolamine class of drugs. 05

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1. (a) Explain the following terms with suitable examples: 06
   1. Mucolytics
   2. IBS
   3. Antacids
2. (b) What is prokinetic agent? Explain it in-detail with examples and mechanism of action. 05

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3. (c) Write a note on following: 05
   1. Anti-emetics
   2. Expectorants

1. (a) What is peptic ulcer? Give a brief note on H2-antagonists. 06
2. (b) Give classification of H1-antagonists. 05

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3. (c) Write a note on laxatives and anti-tussive agents. 05

1. (a) What are anti-asthmatics? Classify it with examples and give its mechanism of action. 06
2. (b) Describe proton pump inhibitors with mechanism of action. 05
3. (c) Write synthetic procedure and uses of following: 05
   1. Diatriazoic acid
   2. Omeprazole

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1. (a) What are eicosanoids? Describe its biosynthesis. 06
2. (b) Write a note on eicosanoids approved for human clinical use. 05
3. (c) Give synthesis and uses of following: 05
   1. Cetrizine
   2. Ranitidine

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1. (a) What are diagnostic agents? Give a detail note on radiopharmaceuticals. 06
2. (b) Give SAR of cholinomimetics and synthesis of diphenhydramine. 05
3. (c) What is medicinal chemistry? Write a note on history of medicinal chemistry. 05

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