Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B.Ph. - SEMESTER- 5 EXAMINATION — SUMMER -2020Subject Code: BP501TT Date: 26-10-2020
Subject Name: Medicinal Chemistry I
Time: 2:30 PM TO 5:30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Enlist various histamine receptors. Discuss neurochemistry of histamine. (06)
(b) Give the synthesis of Promethazine hydrochloride and diphenhydramine hydrochloride. (05)
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(c) Write a note on Nitroglycerin as a Vasodilator. (05)
Q.2 (a) Classify Diuretics with one structure in each class. Write mechanism of action, uses and side effect of Acetazolamide. (06)
(b) Write informative note on Anti-hypertensive agents and give the synthesis of Methyldopate hydrochloride. (05)
(c) Write a note on Gastric Proton pump inhibitors. (05)
Q.3 (a) Classify Antiarrhythmic agents with one structure in each class. Write synthesis of Disopyramide phosphate. (06)
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(b) Write short notes on heparin as anticoagulant and give the synthesis of Warfarin. (05)
(c) Give the synthesis the following: (Any two) (05)
(i) Isosorbide dinitrite (ii) Chlorthiazide (iii) Furosemide.
Q.4 (a) Explain in detail the nomenclature and stereochemistry of steroidal compounds. (06)
(b) Write a note on Anti-hyperlipidemic agents. (05)
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(c) Write informative note on Sex hormones. (05)
Q.5 (a) Give the synthesis and uses of the following: (Any two) (06)
(i) Tolbutamide (ii) Benzocaine (iii) Dibucaine.
(b) Write a note on Antithyroid agents. (05)
(c) Write a note on the natural products used as antineoplastic agents. (05)
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Q.6 (a) Define and classify Antidiabetic agents. Give the synthesis of Procaine. (06)
(b) Classify anti neoplastic alkylating agents with relevant examples. (05)
(c) Write a note on Oral contraceptives. (05)
Q.7 (a) Discuss the SAR of Local anesthetics. (06)
(b) Write a note on Drugs used in Congestive Heart Failure. (05)
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(c) Write a brief note on H2-antagonists. (05)
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