Download GTU B.Pharma 2020 Summer 8th Sem 2280003 Pharmaceutical Chemistry X Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2020 Summer 8th Sem 2280003 Pharmaceutical Chemistry X Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM ? SEMESTER VIII ? EXAMINATION ? SUMMER -2020
Subject Code: 2280003
Date: 27-10-2020
Subject Name: PHARMACEUTICAL CHEMISTRY- X
Time: 10:30 AM TO 1:30 PM
Total Marks: 80
Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
(a)
Define Positive Ionotropic agents with examples & structures. Explain chemistry 06
of Cardiac glycosides in detail.

(b)
Write a short note on (I) Organic nitrates (II) Calcium channel blockers
05

(c)
What is obesity? Write a note on anti obesity drugs.
05




Q.2
(a) Classify antianginal agents. Explain SAR activity of Cardicac glycosides.

06

(b) Write a chemical name & synthesis of Lignocaine & Nifedipine.
05

(c) Explain angiotensin I & angiotensin II blockers with examples & structures.
05



Q.3
(a) Classify anti hypertensive agents with examples & structures.
06

(b) Write a short note on Plasma expanders.
05

(c) Explain SAR activity of HMG ? Co A reductase inhibitors.
05



Q.4
(a) What is re-entry phenomenon? Explain electrophysiological mechanism of anti
06
arrhythmic agents.

(b) Give the examples of Statins with structures & explain hydrolytic inhibition of
05
HMG CoA reductase enzyme.

(c) Write a chemical name & synthesis of Glyceryltrinitrate & Clofibrate.
05



Q.5
(a) Give the examples of first & second generation of Sulfonylureas with structures.
06
Add a note on insulin.

(b) Explain SAR activity of ACE inhibitors.
05

(c) Write a chemical name & synthesis of Metformin & Warfarin.
05



Q. 6
(a) What is high-ceiling diuretics. Classify diuretics with examples & structures.
06

(b) Write a short note on (I) Mineralocorticoide receptor antagonist
05
(II) Sulfonamide derivatives

(c) Enlist different types of sex hormones with examples & structures & explain any 05
one in detail.



Q.7
(a) Explain steroid nomenclature, strereochemistry & numbering system in detail.
06

(b) Explain SAR activity of androgens & anabolic agents.
05

(c) What are adrenocorticoids? Give biosynthesis of Aldosterone & Hydrocortisone. 05

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