Download GTU B.Pharma 2019 Winter 3rd Sem BP301TP Pharmaceutical Organic Chemistry Ii Question Paper

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Seat No.: Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

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B.PHARM - SEMESTER- 3 EXAMINATION - WINTER -2019

Subject Code: BP301TP Date: 14-11-2019

Subject Name: Pharmaceutical Organic Chemistry II

Time: 10:30AM TO 01:30PM Total Marks: 80

Instructions:

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1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1

(a) Write down the methods of preparation and uses of benzoic acid. 06

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(b) Halogens are deactivators but o, p- directors. Justify with suitable examples. 05

(c) Write the principle and significance of Iodine number. 05

Q.2

(a) Write a short note on Fries Rearrangement and Carbylamine reaction. 06

(b) Write the mechanism of Friedel-Crafts alkylation with its limitations. 05

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(c) Enumerate the influence of substituents on the acidity of Aromatic acids. 05

Q.3

(a) Convert the following: 06

1. Phenol to Phenyl acetic acid
2. p-cresol to p-NO2 benzyl tolyl ether

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3. o-cresol to N-nitroso 2-methyl Phenol

(b) Describe in detail about Bayer’s strain theory with its limitation 05

(c) Write an informative note on Huckel’s rule of aromaticity. 05

Q.4

(a) Comment on the following: 06

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1. Why Benzene undergoes Substitution reaction instead of addition reaction? Justify
2. Why reactivity of NO2 benzene is slow in comparison to Benzene.

(b) Why animal fats are solids and Vegetable oils are Liquids? Justify with examples 05

(c) Describe three different reactions of fatty acids with examples. 05

Q.5

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(a) What happens when Anthracene reacts with the following? Write the reaction. 06

1. Maleic anhydride
2. Na/C2H5OH
3. Na2Cr2O7

(b) Write down any five methods of Preparation of Phenol 05

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(c) Write down methods of Preparation of Naphthalene. 05

Q.6

(a) Convert the following: 06

1. Chlorobenzene to Benzene
2. Styrene to 2-Phenyl Ethanol

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3. Benzene to m-nitro benzaldehyde

(b) Write the synthesis and utility of Diazonium salts. 05

(c) What do you mean by [unclear text]? Explain in detail with example. 05

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Q.7

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(a) Describe the various qualitative tests of phenol. 06

(b) Write down the structure and uses of the following: 05

a) DDT b) Saccharin c) Diphenylmethane d) Phenanthrene e) Cresol

(c) Write a short note on Sachse-Mohr’s theory. 05

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