Download GTU B.Pharma 2019 Winter 6th Sem 2260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry Ii) Question Paper

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Seat No.: Enrolment No.

Subject Code: 2260004

GUJARAT TECHNOLOGICAL UNIVERSITY

B.PHARM - SEMESTER- 6 EXAMINATION — WINTER -2019

Subject Name: Pharmaceutical Chemistry — VIl (Medicinal Chemistry - Il)

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Time: 02:30 PM TO 05:30 PM

Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

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1. Write in brief about different theories of drug receptor interactions. (06)
2. Discuss the factors affecting drug receptor interactions. (05)
3. How drug metabolism is helpful in drug design. (05)

1. Explain Phase | reactions of drug metabolism in brief. (06)
2. What is CYP450 and give its importance. (05)

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3. Write SAR of tricyclic antidepressants. (05)

1. Explain Analeptics and Hallucinogens. Give synthesis of Imipramine. (06)
2. What is epilepsy ? Classify antiepileptics with examples. Give synthesis of Phenytoin. (05)
3. Define hypnotics and sedatives and give SAR of barbiturate derivatives. (05)

1. Classify local anesthetics with examples. Write their mechanism of action. (06)

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2. What do you mean by psychiatric disease? Give SAR of Phenothiazines. (05)
3. Write short notes on DMARDS. (05)

1. Give IUPAC name and synthesis of the following drugs :
   (i) Lignocaine: (ii) Indomethacin (iii) Diclofenac (06)
2. Write short note on Alzheimer’s disease. (05)

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3. Classify NSAIDs: and give their mechanism of action. (05)

1. What are different reasons of Parkinson’s disease. Give synthesis of L-dopa. (06)
2. Explain the term receptor and write about different types of receptors. (05)
3. Write short note on cognition enhancers. (05)

1. Write IUPAC name and synthesis of the following drugs :
   

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   (i) Phenobarbitone (ii) Thiopentone sodium (ii) Carbamazepine. (06)
2. Explain in brief factors affecting drug metabolism. (05)
3. Write in short about conjugation reactions of drug metabolism. (05)

Date: 04-12-2019

Total Marks: 80

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