Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
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B. Ph. - SEMESTER-VI EXAMINATION — WINTER -2019Subject Code: 260004 Date: 04/12/2019
Subject Name: Pharmaceutical Chemistry-VIII (Medicinal Chemistry-I1)
Time: 02.30 PM to 05.30 PM Total Marks: 80
Instructions:
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- Attempt any five questions.
- Make suitable assumptions wherever necessary.
- Figures to the right indicate full marks.
Q.1 (a) Write a note on ionotropic receptors. 06
(b) Describe various theories of drug-receptor interaction. 05
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(c) Discuss the factors affecting the drug-receptor interaction. 05Q.2 (a) Define xenobiotics. Describe any four oxidative reactions of phase-I metabolism. 06
(b) Explain hydrolytic reactions of phase-l metabolism with examples. 05
(c) Define conjugation reactions of drug metabolism. Write about sulfate conjugation. 05
Q.3 (a) Describe the SAR of muscarinic antagonists. 06
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(b) Write the mechanism of action and one example with structure of reversible and irreversible anticholinesterases. 05(c) Write the synthesis of dicyclomine and isoprenaline. 05
Q.4 (a) Classify the sympatholytics with chemical structures. 06
(b) Write a short note on ganglion blockers. 05
(c) Discuss the structural modifications phenyl ring of phenylethanolamines. 05
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Q.5 (a) Write a note on tricyclic antidepressants. 06
(b) Define hallucinogens. Write the examples of them which are unrelated to monoamine neurotransmitters. 05
(c) Write the synthesis and use of amphetamine and imipramine. 05
Q.6 (a) Explain the SAR of phenothiazines as antipsychotic drugs. 06
(b) Classify the anxiolytics with chemical structures. 05
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(c) Write any two classes of antiepileptics. 05Q.7 (a) What are opioid analgesics? Discuss about benzomorphan class of them. 06
(b) Write the examples with structures of selective COX-Il inhibitors. 05
(c) Define DMARDs. Discuss gold compounds used as DMARDs. 05
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This download link is referred from the post: GTU B.Pharm 2019 Winter Question Papers || Gujarat Technological University
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