Download GTU B.Pharma 2019 Winter 6th Sem 260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry Ii) Question Paper

Download GTU (Gujarat Technological University Ahmedabad) B.Pharma (Bachelor of Pharmacy) 2019 Winter 6th Sem 260004 Pharmaceutical Chemistry Viii (Medicinal Chemistry Ii) Previous Question Paper

Seat No.: _____ Enrolment No. _____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B. Ph. - SEMESTER?VI EXAMINATION ? WINTER -2019
Subject Code: 260004
Date: 04/12/2019
Subject Name: Pharmaceutical Chemistry-VIII (Medicinal Chemistry-II)
Time: 02.30 PM to 05.30 PM
Total Marks: 80

Instructions:


1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1
(a) Write a note on ionotropic receptors.
06

(b) Describe various theories of drug-receptor interaction.
05

(c)
Discuss the factors affecting the drug-receptor interaction.
05



Q.2
(a) Define xenobiotics. Describe any four oxidative reactions of phase-I
06
metabolism.

(b) Explain hydrolytic reactions of phase-I metabolism with examples.
05

(c)
Define conjugation reactions of drug metabolism. Write about sulfate
05
conjugation.



Q.3
(a) Describe the SAR of muscarinic antagonists.
06

(b) Write the mechanism of action and one example with structure of reversible
05
and irreversible anticholinesterases.

(c)
Write the synthesis of dicyclomine and isoprenaline.
05



Q.4
(a) Classify the sympatholytics with chemical structures.
06

(b) Write a short note on ganglion blockers.
05

(c)
Discuss the structural modifications phenyl ring of phenylethanolamines.
05



Q.5
(a) Write a note on tricyclic antidepressants.
06

(b) Define hallucinogens. Write the examples of them which are unrelated to
05
monoamine neurotransmitters.

(c)
Write the synthesis and use of amphetamine and imipramine.
05



Q. 6
(a) Explain the SAR of phenothiazines as antipsychotic drugs.
06

(b) Classify the anxiolytics with chemical structures.
05

(c)
Write any two classes of antiepileptics.
05



Q.7
(a) What are opioid analgesics? Discuss about benzomorphan class of them.
06

(b) Write the examples with structures of selective COX-II inhibitors.
05

(c)
Define DMARDs. Discuss gold compounds used as DMARDs.
05
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