Download GTU B.Pharma 2019 Winter 7th Sem 2270001 Dosage Form Design I Question Paper

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GUJARAT TECHNOLOGICAL UNIVERSITY

B. Ph. - SEMESTER-VII* EXAMINATION — WINTER-2019

Subject Code: 2270001 Date: 15/11/2019

Subject Name: Dosage Form Design I

Time: 10:30AM TO 01:30PM Total Marks: 80

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Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

1. (a) Enlist various methods for measurement of bioavailability. Discuss any one in detail. 06

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2. (b) What are similarity factor and dissimilarity factor, how are they calculated and give their significance. 05
3. (c) How the bioavailability of the drug can be improved. 05
4. (a) Discuss the significance of protein binding of the drugs. 06
5. (b) What do you mean by prodrug. Give its applications for improving stability of the drug. 05
6. (c) Describe active transport as a mechanism for the passage of drug through biological membranes. 05

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7. (a) Discuss the physiological factors influencing the drug absorption. 06
8. (b) Explain the role of polymorphism and crystallinity in preformulation. Enlist the methods to identify polymorphism. 05
9. (c) Explain in detail film theory as one of the theories of dissolution. 05
10. (a) Discuss the regulatory requirements for the conduction of bioequivalent studies. 06
11. (b) Write a note on Natural gums as pharmaceutical excipients. 05

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12. (c) Discuss the influence of container and closures on product stability. 05
13. (a) Explain: self life, climatic zones, overages. 06
14. (b) Explain accelerated stability study as per ICH guidelines. 05
15. (c) Discuss the factors affecting stability of the drug. 05
16. (a) Discuss the role of active tubular secretion and tubular reabsorption on renal drug excretion. 06

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17. (b) Describe the influence of BBB and CSF barriers on distribution of drugs. 05
18. (c) Enlist the examples of semi synthetic cellulosic derivatives and discuss any two. 05
19. (b) Explain the influence of chemical properties of drugs on formulation and stability of the products. 08
20. (b) Write a note on compendial /n-vitro dissolution apparatus. 08

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