Download GTU B.Pharma 2019 Winter 8th Sem 2280008 Bioavailability And Therapeatic Drug Monitoring Question Paper

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Seat No.:

Subject Code: 2280008

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Enrolment No.

GUJARAT TECHNOLOGICAL UNIVERSITY

B.PHARM - SEMESTER- 8 EXAMINATION — WINTER -2019

Subject Name: Bioavailability and Therapeutic Drug Monitoring

Time: 02:30 PM TO 05:30 PM

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Date: 27-11-2019

Total Marks: 80

Instructions:

1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.

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3. Figures to the right indicate full marks.

1. (a) What is Invitro-Invivo correlation studies? Explain it in detail. 06
   (b) Explain factors affecting bioavailability. 05
   (c) Discuss the role of clinical pharmacist in TDM. 05
2. (a) Enumerate Immunoassay methods used in TDM. Explain RIA in detail. 06
   

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   (b) Explain collection & storage of body fluid samples. 05
   (c) Write down criteria for selection of methods of TDM. 05
3. (a) Define Bioavailability and Bioequivalence. Discuss objectives of BA studies. 06
   (b) Explain methods and parameters of assessing bioavailability. 05
   (c) Explain HPTLC techniques used in TDM. 05

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4. (a) Explain study designs and analysis of BA-BE studies. 06
   (b) Write down TDM for Gentamycin. 05
   (c) Write adverse drug reaction & drug interaction of Theophylline. 05
5. (a) Write down TDM for Phenobarbitone. 06
   (b) Write various problems of interference of biological matrix. 05
   

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   (c) Write a note on determination-of AUC. 05
6. (a) Write techniques used for estimation of lidocain & phenobarbitone. 06
   (b) Explain theories of dissolution. 05
   (c) Write a note on ELISA. 05
7. (a) Write down TDM for Digoxin. 06
   

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   (b) Explain algorithm for interpretation of TDM result for drug used as prophylactic therapy. 05
   (c) Write a note on first pass clearance. 05